I've found muting npubs to be ineffective for the most part. Instead ai use amethysts's hidden words which prevents me from having to see illegal and just gross content where they continually rotate the npub.
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you can mute whole image hosts in amethyst
I muted all images from misskey (mastodon's version of blossom)
now there's basically no hentai in global.
I'm muting all fully clothed pics of people, all cartoons, and clothed pics of animals. Just nekkid animals and people. And no words.
That is an outstanding tip