Thread

Just saw this a few days ago too. 🧬 https://v.nostr.build/qLwcl5qKZrKKtML8.mp4

What is cool is that they aren't relying on apoptosis to prevent cancer, which is basically what humans have to do and which coinicidentally (?) every religion has some sort of fasting ritual, which whether the point or not, induces apoptosis. These guys and whales just repair their broken strands 🤯 we are so close to extending life and health span 🤞 (Lots of which's but I ain't rewriting that, hopefully a point emerges anyways 😅😆)

It seems that destruction of precancerous cells via autophagic-induced apoptosis (while fasting or otherwise) is the trade-off the DNA of humanity chose — perhaps in favor of more aggressive proliferation. Now that the human race is highly evolved, we may be able to shift that trade-off away from indiscriminate apoptosis of mildly damage cells to only inducing apoptosis in cells that are resistant to these advanced forms of DNA repair! 🧬 I wish nostr:npub1sg6plzptd64u62a878hep2kev88swjh3tw00gjsfl8f237lmu63q0uf63m would get interested in longevity — after what happened to Hal and ALS, it would be nice to see an extropian revival. The original cypherpunks were extropians after all.

I’m curious if there are studies showing how cell replication halts during DNA repair, at least in the cells being repaired. Hence why I said humanity’s DNA may have prioritized aggressive proliferation over stopping growth to repair DNA.

I recall reading this study in 2018: An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis https://www.sciencedirect.com/science/article/pii/S1097276519307944 Autophagy and its DNA repair can be suppressed during cell division/growth.

They also have a heart rate of ~10 bpm, aligning with other creatures that greatly outlive us (greenland shark, giant tortoise).

Don't have time to read this rn, but will later this week. Jack shared a pic of his HRV so I guarantee you he is into longevity on some level. Maybe I will start a longevity relay so he will be tempted into browsing ha.

10 bpm is 🤯. I am happy with 56 bpm at night lol

56 is excellent! I only mention their heart rate because this is "in mice" on steroids. Bowhead whales also take about twice as long to sexually mature as we do. They're living their whole life at a slower pace. CIRBP prevents cell death due to hypothermia so this is probably good for a whale that lives in Arctic waters. CIRBP is associated with both the prevention and proliferation of different cancers. It's also associated, both positively and negatively with different aspects of Alzheimer's. There will probably be targeted treatments for certain conditions in the future but upregulating this simply for potential longevity benefits will be risky.

Right, that makes sense. We cannot take that which occurred in some cells and extrapolate to an entire organism that has a completely different developmental timeline and physiology. I do hope there could be targeted treatments that are drawn from this, though. That would be great for humanity.