You don't need to use a lot of clients, no. Under settings (in yakihonne, if that is the client you like) find your relay settings, add wss://spatia-arcana.com as a "read" relay. "Read relays" are where replies, likes, etc to your notes are sent. Yakihonne will connect to those relays to get your replies for you. You have a lot of relays there right now. You only need 2-3. If you choose to use only wss://spatia-arcana.com for that, your notifications will be filtered by the relays criteria, which is quite strict.

Oh you have it there now! You're set. I would still recommend dropping a couple more of the read relays. You will have a smoother experience. As far as using many clients, some do things different or better than others. Some do completely different things all together. fevela.me is nice for browsing a single relay's contents, as if it is it's own mini social media feed. Yakihonne does that well, too. If you're uncomfortable hopping around between clients, I'd stick with the one you like until you get a bearing on the way data moves around. You don't need to change your relays every time you visit a new client. Those settings follow your profile.