it also synergises with nicotine to make that even worse
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also, the ones with sucralose and acesulfame-K are nephrotoxic. i lost my perfect vision because of that. also fucked up my muscles and neuromuscular function (the latter being how it messed up my vision, i have a convergence problem now at short distances, that makes my focus weaker).
Did you mean caffeine? Or basically coffee and cigarettes = bad?