Advice to self never have CoQ10 on an empty stomach before bed 🤦
Short answer: yes, CoQ10 can upset your stomach in some people — but it’s usually mild and manageable.
From your photo, this is Bioglan CoQ10 – 150 mg ubiquinone, which is a moderately high dose. At that level, digestive side effects are more likely than with lower doses.
Common stomach-related side effects
These can happen especially when starting or at higher doses:
Nausea
Stomach pain or discomfort
Heartburn / reflux
Diarrhea
Loss of appetite
Feeling bloated
Why it happens
CoQ10 is fat-soluble, so it can irritate the stomach lining if taken on an empty stomach
150 mg in one hit can be a lot for sensitive guts
Some people react to the capsule oils or fillers, not the CoQ10 itself
How to reduce stomach issues
If you want to keep taking it:
✅ Always take it with a meal (ideally with fat)
✅ Consider splitting the dose (75 mg morning + 75 mg later)
✅ Avoid taking it with coffee on an empty stomach
✅ Don’t take it right before bed (can cause reflux + insomnia)
When to stop and be cautious
Stop and reassess if you get:
Ongoing vomiting
Severe abdominal pain
Black stools
Persistent diarrhea
Also important: CoQ10 can interact with blood pressure meds, blood thinners (like warfarin), and statins.
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If you want, you can tell me:
Are you getting nausea, cramps, diarrhea, or reflux specifically?
Did you take it with food or on an empty stomach?
I can narrow down exactly what’s happening.
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