To meet in the middle on one point, I think one can be trans if they have transitioned from one social pattern to another that better matches their predilections - which AFAIK is what the non-anti-science ones are claiming after all.
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Is it social patterns that make a person a man or a woman? Or is defining people by social patterns more akin to some form of stereotyping & bigotry...? Because I think many of the famous "trans" people are really just making a mockery of the opposite sex.