How are we going to fight spam bots? I already see some automatically posting replies to posts. It will be impossible to out-mute them as they can create infinite new nsecs at no cost.
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Web of trust.
You could auto-mute anyone who is completely outside your web of trust without any one step connection to accounts you know. And the ability to see it in the list so you can expand, versus completely hiding it could also be based on degrees of separation. ie. More than 6 degrees? Hide completely. 5 degrees or less, leave a “show post” option for muted comments.
Leveraging the web of trust is a massively underappreciated tool, imo.
We can leverage the web of trust by creating a crowd based decentralized sorting function called #peercuration A bonus it that it will help solve the issue with centralized relays: 
GitHub
GitHub - baumbit/peercuration
Contribute to baumbit/peercuration development by creating an account on GitHub.
Six Degrees of Separation was a great film, honestly..... 👊🏻