Caffeine is probably the one that invaded our society on the largest scale, it's pretty much overlooked and it has awful side effects.

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Caffeine has negative effects on your sleep cycle. It can lead to the development of anxiety both due to its consumption and because it can cause you to sleep less. Additionally, its consumption can also lead to tachycardia and hypertension. Considering that heart attacks and heart failures are the leading causes of death worldwide, I'd stay away from caffeine.