In a perfect world, eat a big breakfast, eat a smaller dinner, and skip lunch. Always eat dinner while the sun is still out. You're built that way by nature Tone Vays: "So I used to be OMAD, one meal a day. I was not able to build any muscle with one meal a day. I had to switch to two meals a day. I still try to keep my 16 to 18 hour fasting window, and eat within 4 to 6 hours. Now, for social reasons, I skip breakfast so I could eat an early lunch after a workout and then dinner. In a perfect world. . ." Dr. Jack Kruse: "You would scrap that." Tone Vays: ". . . I would eat breakfast and lunch, and scrap the dinner." Dr. Jack Kruse: "No, I would tell you in a perfect world, you're going to eat a big breakfast, and you're going to eat a smaller dinner, and you're going to skip lunch. And then you're really going to be cooking with gas." Tone Vays: "I'm trying to keep the window as small as possible, but eight hours is my max window." Dr. Jack Kruse: "Yeah. But I would tell you where you're putting your window is also a problem. Remember what the word is called: breakfast. You're breaking the fast at night. "So here's the other part that we didn't talk about, but we need to. When you get the leptin prescription right, you're going to find that you're always going to eat dinner while the sun is still out. Now, you've been here for a couple days. You know that it gets dark here at six o'clock this time of the year. So, guess what that means? I'm always eating my dinner [...] 04:00 to 05:00. [...] Then you don't eat again until" Tone Vays: "Breakfast." Dr. Jack Kruse: "Right." Tone Vays: "Until sunrise." Dr. Jack Kruse: "And that's going to be at 06:30. [...] And that's how you should do it because that's how you're built by nature. You're not built that way from a paper, you're not built that way from a food guru, you're built that way by nature. That's the decentralized nature of us. And if you stay to that plan, and understand like when you go back to Russia, like the time, the light preference in Moscow is radically different than it is where it is here. You know that. So you're going to adjust that template there. That's when you may say, 'Jack, I'm going to do the breakfast, but I'm going to eat lunch and I'm going to do it at 01:00.' Why? Because it's going to get dark in Moscow at 03:00." Dr. Jack Kruse with Tone Vays @ 29:08–30:59 (posted 2025-11-15)

Heparan sulfate depleted in the brain of autistic kids. Heparan sulfate relies upon sulfate being attached by enzymes that are disrupted by glyphosate. Sunlight triggers the growth of heparan sulfate Dr. Stephanie Seneff: "I was looking at sulfate and autism. I have found papers that show, even postmortem, they showed that heparan sulfate was severely depleted in the brain of the autistic kids. Heparan sulfate is […] a very complicated sugar molecule, lots of sugars all connected together with sulfates sticking out of them in various places. That's the molecule that lines all the blood vessels. It also goes around the cells, both the cells in the blood and also just the cells and the tissues, they're all surrounded by heparan sulfate, which is hooked into the cell membrane. And the heparan sulfate has variable amounts of sulfate in it, so you can stick them in various places or not. "And the autistic kids have have low sulfate in their blood, and they also have low amounts of heparan sulfate […] I suspect everywhere. I mean certainly it's been shown up in the brain, both for the children and for the mice, they've studied mice. In fact, they had one group of mice in this experiment with all they did was injected something into their into their brain ventricles in the middle of the brain a chemical that prevented them from making heparan sulfate, and those mice, and prevented them from adding sulfate to the heparan sulfate, and those mice developed all the characteristic mouse symptoms of autism. So that was very dramatic with just that one change. They were normal mice except for that, and so that's really pointing to the heparan sulfate deficiency as being a core feature of autism. "And the heparan sulfate relies on the sulfate that's getting attached by all these enzymes that are being disrupted by glyphosate. So it's difficult to transport sulfate if you can't hook it onto something. The body relies on hooking it onto an organic molecule to ship it around in the blood, because if you put too much sulfate in the blood it'll gel the blood, and you don't want it to be jelly. It has to flow. So they've got this trick of sticking it onto these molecules that will go into lipid membranes and keep it away from the main circulating blood. "So they need to have a low level of sulfate in the blood, yet you need to deliver sulfate to all these places. So the body has come up with a clever solution to do that which involves these enzymes that glyphosate suppresses. So we get into big trouble with insufficient sulfate, and the sulfates are what makes the water gelled. Lining all the blood vessels is this slick layer of Jell-O so the red blood cells can just slide through effortlessly. That's really important for the circulation of the red blood cells, because the capillary is kind of a tight squeeze for the red blood cell, unless it's got really easy, low friction in the boundary, it's going to be hard for it to get through. So it's critical for the blood circulation. "And then the gel creates this battery which is so cool, and that's Gerald Pollack's work. […] He's done all these experiments where he shows that the gel that's created by the sulfates creates a battery, and the protons actually are pushed out from the gel. […] "And of course it's sunlight too, because sunlight is what triggers the growth of the heparan sulfate. That's important, and Gerald showed that as well, especially infrared light can grow that, well he calls it exclusion zone water, because it excludes. It becomes like pure water, and then the protons are being pumped out. It's using the sunlight as a source of energy. So it becomes a solar panel, in a way." Dr. Stephanie Seneff with Aastha Jain Simes @ 37:40–41:41 (posted 2024-05-30)

"I never use methylene blue orally." You can potentially ruin your gut microbiome Tone Vays: "Sticking with the mitochondria, right now I'm testing out a few things. So I've been doing methylene blue for about a month." Dr. Jack Kruse: "How do you do it?" Tone Vays: "Uh, I have a liquid that I put in water." Dr. Jack Kruse: "You don't do that." Tone Vays: "You know, this is what I was going to ask. And I don't feel any different. […] And my biggest problem with it is it's such an artificial thing. I just feel uncomfortable drinking something that was created. […] What are your thoughts on methylene blue? Should an average person use it? Who should use it? And how should they use it if they need to use it?" Dr. Jack Kruse: "The number one thing you need to understand is context. Who are the doctors that are experts in using methylene blue? Cardiovascular surgeons and neurosurgeons. What's my day job? I'm a neurosurgeon. […] "So I want you to understand what methylene blue is really used for. It can be an antimicrobial. So if you're taking it this way [points to his mouth], you're killing your gut microbiome. "The only way cardiovascular surgeons use it and neurosurgeons use it is IV. That's the only way it should be used, and then it knows what they're doing. […] If you take it orally, you potentially can ruin your microbiome. It's a great way to screw things up. Then you make the hole deeper, and then you won't know where to go from there. "So, my two cents, I have a Patreon blog that tells you specifically when and when not to use it. I also believe that you need to have a decentralized doctor under your care to tell you whether it's a good thing for your current template. But I never use methylene blue orally." Dr. Jack Kruse with Tone Vays @ 15:47–17:54 (posted 2025-11-15)

Dr. Petra Davelaar's checklist for optimizing fertility Dr. Petra Davelaar: "The first thing we have to address light. You have to watch the sunrise every morning, and this will help establish all of the right hormonal issues that may be going on in either one of the couple. […] "Become acutely aware of the light you are under the whole day, every day, and address that. Replace all the light bulbs, get rid of the LEDs, CFLs, and change all of that. […] "Ditch your sunglasses. No sunscreen. […] You have to rebuild your melanin and your dopamine pathways, crucial pieces. And we can only do that with sunlight. We have to be out there as much as possible. […] "Become really aware of all of your electromagnetic radiation that you are exposed to. Manage your tech. Understand that we should not use these laptops without an Ethernet cable. […] Never wear your cell phone on your body. […] Men, get them out of your pocket. […] "Water. […] You need to make sure that you avoid fluoride. Drink the best quality water that you can have access to, spring water, structured water. Avoid municipal water. At least run it through an reverse osmosis filter if you are going to be drinking that. If you can afford it, use deuterium-depleted water for a period of time if you're trying to optimize fertilization. […] "Improve your breathing. […] Slow it down, less deep. Breathe through your nose, not through your mouth. Clear this whole piece of night breathing, mouth tape, whatever you need to do to get yourself to normalize this breathing function. Reduce the amount of breaths you take every minute. […] "Foods. Simple. Consume local and seasonal. […] Eliminate all the processed foods, your supplements, your creatine, your protein bars, your shakes. […] No fortified ones. Most grains contain all sorts of things we don't want. So yeah, just real food. […] "Body care. […] Get rid of all the shampoos, the fluoride toothpaste, the body creams, hair products, regular soaps. Get as natural as possible. […] "Clothing. When you're outside, you want to expose as much as your body as you can to the sunlight. No polyester underwear, no wired bras and shaped with chemicals types of things. […] Focus on those that […] are better for us, that will be your cotton, your linens, and so forth. "Medications. Educate yourself on vaccines and question how they may play a role during and after fertility, as well as for your children. It's going to be the first huge medical decision you make for them. Be aware of what's coming on day one when you give birth in a hospital. Just get your ducks in a row. And in fact, I just spoke to a doctor, Edward Geehr, who published a book in 2024 called […] _Unavoidably Unsafe_. […] We should all read that. […] "And then any medications that someone is on, should you be on these? Should you try and get off of them? Should you be on antidepressants? And can we manage this differently? And would that give my child a better chance? I think all of those are worth considering. "And then of course, yeah, enjoy life. All the right things, and not make it too complicated." Dr. Petra Davelaar & Dr. Doug Sandquist with Logan Duvall @ 26:00–32:16 (posted 2025-08-28)

Your quads, glutes and hips are the first to weaken with age. Three simple exercises to help you live independently "The muscles that help you stand up, your quadriceps, glutes and hips, are the first to weaken with age. They're also the ones that determine whether you can live independently. The stronger they stay, the longer you stay free. […] "Today, I'll walk you through three simple, science-backed exercises that thousands of Americans over 60 are using to rebuild their legs, improve circulation, and regain balance right from their living room. These are not workouts. They're signals your body understands. Let's bring that strength back, one small step at a time. […] "This first exercise […] looks small, but it flips the switch that wakes your circulation. […] Sit in a sturdy chair, feet flat on the floor, back straight, shoulders relaxed. Now, lift your toes towards you, hold one heartbeat, then press them down, and lift your heels. Feel that rhythm: Heel toe, heel toe, like a slow wave rolling through your ankles. Keep breathing. 10 to 20 reps per set, up to three sets a day. […] "The next challenge is teaching those newly revived muscles how to stabilize your entire body when you stand, […] the exercise that turns trembling legs into steady pillars again. […] "Stand behind a sturdy chair or at your kitchen counter. Hold on lightly, just enough for balance, and place your feet shoulder width apart. Now slowly rise onto your toes. Pause at the top. Feel the stretch along your calves, and then lower yourself back down with control. No bouncing, no rushing, just steady, deliberate movement. 10 repetitions, rest for a minute, then repeat. Work your way up to three sets of 20 over time. […] "If the ankle pumps wake your circulation, and the calf raises restore balance, this final movement rebuilds your raw power, the ability to rise, to climb, and move through the world on your own terms. […] "Take a sturdy chair, one that doesn't roll, and place one or two firm pillows on the seat. Sit down slowly, feet flat, knees in line with your toes, hands resting lightly on your thighs. Now press your feet into the floor, tighten your core, and rise until you're fully standing. Pause. Feel your legs engage. Then lower yourself back down until you just touch the pillow. That gentle tap keeps your muscles under control rather than letting gravity take over. Start with one set of five. Rest. Then build to three sets of 10 as your endurance grows. Don't rush the process. The slower you move, the more your muscles learn precision. And precision builds true strength." HealThrive Talk @ 08:39–08:48, 00:38–01:57, 04:02–05:14 & 08:19–09:34 (posted 2025-11-08)

How to avoid glyphosate. Eat certified organic whole foods, organic eggs, animal fats, butter, sour cream, full-fat milk, half and half. Avoid processed foods. Humic acid and fulvic acid helpful in removing glyphosate from the gut Aastha Jain Simes: "If someone wants to avoid glyphosate as much as possible, what are some practical suggestions you would give them?" Dr. Stephanie Seneff: "Absolutely go on certified organic diet. Only buy certified organic foods, and I would recommend only buying whole foods; don't eat processed foods. Anything that has a whole bunch of ingredients don't buy it, you know, one of the soy protein bar, even organic soy protein bar, I wouldn't buy it. So you want eat high nutrient density foods as well, for example, organic eggs. That's a terrific food because they got so many vitamins and minerals as well as of course sulfur. "And healthy fats. I really recommend animal fats, and I love butter and sour cream. Those are nice low-deuterium fats. Actually interesting, because milk has low-deuterium, and that's intentional, I think, because the infant needs to have low deuterium in its diet. […] I only drink full-fat milk. In fact, if I have cereal I put half and half on it, so even more fat than full-fat milk. […] And by the way, butter has very low deuterium, so natural organic butter is a terrific food. […] So the high fat diet is low deuterium. […] "I mentioned the humic acid and fulvic acid. People are find that that's helpful for removing glyphosate from the gut. And probiotics, I really think if you eat a lot of probiotic foods, it's good anyway, because they can help with your gut microbes. They could have bacteria that could metabolize glyphosate in them. I don't know whether that's true or not, but I would hope that could be." Dr. Stephanie Seneff with Aastha Jain Simes @ 01:13:35–01:14:43 (posted 2024-05-30)

Glyphosate substitutes for glycine, thereby damaging collagen. Glyphosate may contribute to pelvic prolapse, joint pain, neck pain, back pain Dr. Stephanie Seneff: "[…] I called it a glyphosate susceptibility motif that certain proteins have. […] If that glycine is mutated to something else that protein is dead in the water, and there were many proteins that had tremendous sensitivity to substitutions. If glycine is substituted by a different amino acid in the code, that protein is broken. […] Glyphosate is pretending to be glycine. […] When the machinery sees the code for glycine, it grabs glyphosate instead because it fits perfectly. […] That can really mess things up, because the glyphosate has this extra bulky thing that's stuck out into the space. In particular, when they bind phosphate, glyphosate's methylphosphonate unit fits into the place where phosphate from the substrate is supposed to go. So the substrate can't fit anymore and the protein can't do its job." […] Aastha Jain Simes: "What are some of the first order effects of what happens in the body?" Dr. Stephanie Seneff: "Yes. There's so many. Collagen is a good example, because collagen is the most common protein in the body. A third of our proteins are collagen molecules. It forms the glue. It basically is in the connective tissue, in the bones, in the joints, even in the brain. It's very common in our body. And collagen has long swaths of G-X-Y, G-X-Y, G-X-Y, G-X-Y, every third amino acid is a glycine, tremendous opportunity for glyphosate to do mischief. I definitely think that glyphosate messing up collagen is causing a lot of diseases of the bones and joints and even of the gut. "There's a problem with sagging, […] pelvic prolapse, […] where the organs are sort of collapsing down into the bottom of the body, because they can't hold themselves up, because the collagen is so weak and flabby that it can't actually work. This is a kind of condition that's happening, and it can be a pretty serious problem. I think it's because the collagen's not forming correctly, and then […] the connective tissue is not strong anymore; it's too weak. "I think that's causing a lot of problems also in the bones and the joints. People have a lot of issues with joint pain. We have a lot of replacement, hip replacement therapy, and knee joint, you know, knees are giving out. You look at Americans over the age of maybe 60, they're pretty much hobbling around. Many of them have to use a walker or a cane. […] And of course back pain is a huge problem. There's a lot of pain associated with these things: neck pain, back pain. People get on opioid drugs, so now we have an opioid drug crisis. I think glyphosate may be contributing to all of that, because messing up collagen could explain all of that." Dr. Stephanie Seneff with Aastha Jain Simes @ 16:08–17:35 & 19:39–21:50 (posted 2024-05-30)

A high fat diet is the most deuterium-depleted diet. When treating cancer with deuterium-depleted water, avoid taking high dose antioxidants, avoid intense exercise, avoid sauna or hot baths Dr. Max Gulhane: "The question about diet in terms of deuterium. Essentially it's sounds like a high fat, carnivore diet is the most deuterium-depleted diet. Is that correct?" Dr. Gábor Somlyai: "Yeah, I agree. Yeah, sure. So we recommend people when starting to drink DDW at the same time change the diet, some kind of ketogenic-type diet. I never say be strict ketogenic because they cannot keep it on a long term. They should find the best way when they can optimize it and keep it on a long period of time." Dr. Max Gulhane: "Yeah, and Dr. Boros, who I talked to earlier, was talking about the benefit of high fat carnivore for all the reasons of promoting metabolic water function and optimizing mitochondrial function. So to me it sounds like a high fat diet, ketogenic or carnivore-type diet, would be the most optimal to do in addition to drinking the deuterium-depleted water for cancer or for metabolic disease." Dr. Gábor Somlyai: "Yeah. I fully agree. Yes." Dr. Max Gulhane: "Yeah. OK, and again, I think I just want to make the point for my listeners, is that there's no reason why we can't do this therapy in addition to other things, like exercise, like respecting our circadian rhythm and our light environment. It's great that this is simply just another tool in the toolbox. That's how I kind of understand it to be." Dr. Gábor Somlyai: "There are a couple of thing what we do recommend not to do, and this is very important. So for example, I sometimes I didn't understand why the people do not show any improvement even consuming DDW. And later it's turned out those who are taking antioxidants on a high dose, that prevent the efficacy of DDW, and this is the reason of the radicals. So when we are going to trigger radicals, hopefully triggering the necrosis, but if they're taking vitamin C, E, A, selenium, that way we help the cancer cells to work against DDW. This is what we recommend. "The other we do not recommend the exercises and loading test, because then the lactic acid increasing in the blood, no enough oxygen, and all these thing I again found that those cancer patients they were fine starting to doing exercise, they relapse. "And the third is no sauna, no hot bath, because again the higher body temperature modify the metabolism, which again somehow help the cancer cells to treat the challenges of the DDW. "So drinking DDW and not doing that three different thing to optimize the efficacy of DDW." Dr. Max Gulhane: "OK, thank you for making those points. […] Obviously walking is OK. But you're suggesting that high intensity or long distance running is a bad idea." Dr. Gábor Somlyai: "Yeah." Dr. Gábor Somlyai with npub19yjldzc98lsesatjncxzgunm8xpdjsr5tva3sjc9ggyqsjh5hedst2unad @ 01:02:13–01:05:55 (posted 2024-02-24)

"If you don't see the sunrise you cannot properly utilize the TCA cycle. In other words, you can't burn fat, can't use beta oxidation." — Dr. Jack Kruse with Jonathan Jarecki @ 54:53–55:00 (posted 2024-12-23)

Humans' biggest risk is their own Dunning-Kruger effect Dr. Jack Kruse: "At the end of every year, from about I guess it's September 30th to December 15th, I have a notebook, and I write all the things down I currently believe, and then I challenged them. Is there any new data out there that causes me to fix this? "Why do I do that? Because I understand that humans' biggest risk is their own Dunning-Kruger effect. "I came up with this idea 25 years ago when I left residency. I started to think about in real life, we don't have any process like M&M conference, which is morbidity and mortality. I said, 'So how do you stay up to date?' […] I said, '[…] I think the best thing is I need to do this myself. I need to have my own M&M conference.' And that's where I came up with the idea." Dr. Jack Kruse with Jonathan Jarecki @ 35:12–36:08 (posted 2024-12-23)

Steps taken by Sarah Kleiner to get pregnant at age 43. Dr. Kruse's advice Dr. László Boros: "Can I ask a quick question, because you told me in your email that you are 23 weeks?" Sarah Kleiner: "27. 27 weeks now." Dr. László Boros: "Congratulations." Sarah Kleiner: "Thank you. Yeah." Dr. László Boros: "Was your husband also on deuterium-depleting protocols or it was only you?" Sarah Kleiner: "Just me. Just me. We had yeah, I just turned 43. We had decided we're going to try for the baby, and we had been trying for a couple of years and just not successful. And so I changed my whole lifestyle, too. I didn't just drink the water. I mean, that's when I got very interested in circadian rhythms. Anytime I could be in the woods, I was in the woods. I started cold plunging in ice water, 30 degree ice water [laughs], going out on my deck in a bathing suit in the winter and ice plunging. Red light therapy. Just everything I could. And then a ketogenic diet, you know, very high fat, bone marrow, as healthy as I could. "And I did do [deuterium-depleted] water from September to December. And then one of my friends that we're all kind of connected with Dr. Kruse and a lot of his teachings, he said, 'Well, if you're going to try for the baby then stop the water, and stop the cold plunging in January.' And so I stopped it in January and then that was the month that it worked. "And so that's what, you know, during all this time is when I was just super interested in the whole concept of deuterium, because there's so many women that are struggling to get pregnant, not just my age you know. Yeah, I'm older to try to get pregnant, but there's women in their 30s and in their 20s. And when I was exploring different fertility clinics, they're all booked up six months in advance. And then you go and it's full of younger women, too. So it's a major problem right now. Dr. László Boros: "Yeah, because if you think about it, sperm is propelling itself, the sperm cells using these nanomotors. They swim in a liquid where viscosity is very critical to reach the egg, the oocyte that was released from a mature follicle. And all these factors eventually add up, and would help fertilization by deuterium depletion. I would most desirable on both sides, but obviously it would make a big difference even just if you follow a certain lifestyle." Dr. László Boros with Sarah Kleiner @ 34:46–37:34 (posted 2022-08-10)

Chemically made supplements of methionine, melatonin, NAC, choline are not low deuterium. As such, they are harmful. Most of these supplements are chemically made. Biologically made methionine, NAC, melatonin, choline are low in deuterium Tristan Scott: "That's so fascinating in terms of the synthetic. I hate when a lot of these, maybe it's more the Fitness Bros, or the 'Show me the study' guys are like, 'Well, there's no difference between synthetic [methionine] and natural components.'" Dr. Stephanie Seneff: "That is not true." Tristan Scott: "Now it's like, 'Well, we have here some proof that actually there is.' Why is there actually a difference? Is it just because they don't consider those deuterium-depletion steps that our innate biology has built in?" Dr. Stephanie Seneff: "Precisely, yeah. First of all I want to say that melatonin has the same problem. And N-acetylcysteine does, too. So the acetyl in N-acetylcysteine, that's going to be low deuterium if it comes from the gut microbes, but if it's made synthetically it won't. So if you're taking a supplement N-acetylcysteine, no guarantee that that acetyl is going to be low deuterium. "And melatonin, melatonin has both an acetyl and a methyl attached to it. It starts out as tryptophan, which of course comes out of the shikimate pathway. Tryptophan gets turned into serotonin, which is another neurotransmitter. And then serotonin gets turned into melatonin, and when you do that you add a methyl and an acetyl. Both of them are going to be low deuterium if they came from a biological source. "But if you eat a methionine that's made in the chemistry lab, which it typically is, that's how you can do it cheaply. […] Imagine growing microbes and having to purify the methionine that's in there with all the other stuff that's there, right? Or the melatonin. That's a lot of work. So you'd rather just make it chemically. You can get a pure supply more easily if you don't have to deal with all the biological life that might be mixed up in there and cause problems. So most of these supplements are chemically made, and they're not going to be good, so I don't recommend any of these supplements that are going to have these. "Choline is another one. Choline is going to be low deuterium if it comes from a biological source. But if they're making in the chemistry lab, forget it. It's not good for you. So I think people are loading up on supplements that are actually hurting them because they're not supplying the low deuterium resource that would have happened if it had been biological. "Now I need to explain why that's the case, because it's super fascinating. I figured it out based on a paper that was written in the 1960s. […] That paper showed […] that the gas that was made by these [gut] microbes, hydrogen gas, H₂, had 80% of the deuterium gone. It was down by a factor of five. 80% gone. So that becomes a really good source of low deuterium hydrogen. And then the microbes are very careful to make sure […]" Dr. Stephanie Seneff with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 58:17–01:01:20 (posted 2023-12-05)

If you don't wear sunglasses, you don't burn. You're triggering the POMC production in your brain and your skin to make new melanin. Throw out your sunglasses! There's nothing more powerful than melanin; you want more of that Dr. Francisco Gutierrez: "And then the other thing that really caught my attention was the use of sunglasses. I threw them away." Dr. Alexis Cowan: "Great." Dr. Francisco Gutierrez: "And you know, it's crazy. Ever since I've heard you say this in podcast that you've also had the same experience that I'm gonna share, is that after you don't wear sunglasses, you don't burn. Like I can literally be here UV 13. I've been there like two, three, four hours, no burn, zero." Dr. Alexis Cowan: "Yes. It's wild. And it also makes perfect sense too, because then you're triggering the POMC production in the brain and the skin and you're getting basically double the dose of the MSHs that are needed for making new melanin. "Every time I go out in public, it's just crazy the number of people I see wearing sunglasses and AirPods. Like so many people wearing sunglasses and AirPods at the same time. I just want to make a T-shirt that says like, 'Throw out your AirPods and sunglasses!' because this is ridiculous. "And with regards to cycling, I'm big into cycling, too. But I noticed like I go out and I like basically wear like short shorts and like a sports bra and like I'm not wearing glasses or anything. And then I see other cyclists and they're covered with the thin clothes from head to toe, sunglasses, helmet. It's like nothing is showing." Dr. Francisco Gutierrez: "I know. It's crazy. The cycling group that I that I go out cycling, a lot of them are from the Dominican Republic, so their skin is dark. Yet they slather themselves with sunblock and put sunglasses on. In the 44th north latitude." Dr. Alexis Cowan: "Oh, no. That's awful. Yeah that reminds me, there's a brand of sunscreen, I wanted to like burn something down when I read this, but there's a brand of sunscreen called Black Girl Sunscreen [laughs]. And I'm like, 'Oh my gosh.' There's a lot of programming in Western culture around, and also in other cultures too. Even in the East, you're frowned upon for having darker skin, like it's bad. Everybody's trying to have lighter skin because it's supposed to be more aesthetic. But when you learn about the biology of melanin, it's like there's nothing more powerful than that. You want more of that." Dr. Francisco Gutierrez: "You want more of that. Yeah, absolutely. No, I agree." Dr. Francisco Gutierrez with Dr. Alexis Cowan @ 37:53–40:12 (posted 2025-05-23)

Glyphosate damages gut microbiota, raises gut pH, damages acid-loving microbes' ability to make butyrate. The colonocytes lining the gut get sick from a lack of butyrate, which leads to IBD and eventually colon cancer Tristan Scott: "Yeah, I think it's incredible, and that's one of the main mechanisms or areas that people are pretty familiar with is that [glyphosate] is like a nuke for your gut, really. But when you get into how it works and then how something I realized is just how important the gut is for producing things like B vitamins. I think you said in your book that it augments the the dietary intake of it. So that's something that especially folks in the diet community pretty much never talk about, and that care we need to have for our microbiota and just how the diversity has been just decreasing tremendously over decades. If you look at like studies comparing the Hadza in Africa and Tanzania compared to the modern man, it's so crazy." Dr. Stephanie Seneff: "I think I talk about that in my book. I have a chapter on the gut which I've spent a long time on it. The gut is a hard problem when you start looking. The research literature has blossomed. There's tons of papers now, and they're very complex with all these pretty colors, and all these Venn diagrams, and all these different microbes in different amounts, and it's extremely overwhelming. But I eventually dug a story out of that I feel that I'm quite confident about which is super interesting. "Glyphosate causes the pH of the gut to go up, and I think that's because of these undigested peptides. Normally the proteins come in, they get broken down into the amino acids, they get absorbed in the midgut, they get absorbed into the system, and now everybody's happy, because you need those amino acids to make human proteins. "But they don't get digested. They end up in the lower gut still as peptide sequences. And then there's gut microbes there that can break them down, but break them down all the way, because you can no longer absorb those amino acids. They have to be broken down all the way to nitrogen, which is going to be ammonia, which is going to be a high pH. So you raise the pH of the gut, and then that causes the acid-loving microbes to get sick they can't really live in this high pH. Those are the ones that make the acetate, the butyrate, the propionate. These are short-chain fatty acids that are incredibly important for the host, because the colonocytes lining the gut, their main food is butyrate, and butyrate comes from these acid-loving bacteria. And so when they can't make the butyrate, the colonocytes get sick, and then you end up with inflammatory bowel disease and irritable bowel disease, and eventually you get you know colon cancer and things like that, all of which are going up dramatically in step with the rising glyphosate usage in this country." Dr. Stephanie Seneff with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 26:21–28:49 (posted 2023-12-05)

The basic biochemical function of mitochondria is to produce water. We also recycle the metabolic water to produce energy. Once you recycle your metabolic water to produce energy then you have to drink some water or some oil Dr. László Boros: "The most important function of mitochondria, and that's the basic function of mitochondria, is actually to produce water. […] It's not to produce energy. No, no, no. The mitochondria has very little original biological role in generating energy. In evolution it was actually the sun. The reptiles who actually didn't drink water, they were actually making their own water from food. That's why they could propagate in the desert, and they used the sunlight for energy. "Now as we move to the temperate climate we use the mitochondria, we recycle this water, this is why we can produce more energy. But actually the basic biochemical function of mitochondria, and I'd like to emphasize this, as a biochemist, and as a professor at UCLA, is to produce water. This is why you breathe in oxygen, and this is why you harvest food, hydrogens, and you breathe out carbon dioxide, because you don't need the carbons of food, you need the protons, or hydrogens, from food which you attach to oxygen and you make metabolic, or matrix, water. "Now what happens to this metabolic or matrix water, that decides if your mitochondria is producing energy, ATP, or you use this metabolic water as a chemical solvent and you use it for your body's hydration. That's what the animals in the desert do. But obviously they have sunlight so they don't have to produce ATP as much as like we here in the temperate climate." Luke Storey: "So a polar bear then would be not using sunlight to produce energy. […]" Dr. László Boros: "Yeah. That's why they have to eat those big fatty sea lions, because that's the only way they can survive close to the North Pole, simply because they have to generate ATP from their food, and they have to breathe oxygen in, meaning that they produce their own water in their cells, and they recycle that water. This is why they eat snow, because they still have to have water. Once you recycle your metabolic water to produce energy then you have to drink some water or some oil." Dr. László Boros & Dr. Que Collins with Luke Storey @ 49:14–51:49 (posted 2018-10-02)

Every protein that's made starts with methionine. The 'methionine is bad for aging' study was flawed as it used synthetic high-deuterium methionine; the deuterium caused the harm. Cancer as a signal of mitochondria stealing methyls off of the DNA due to too much deuterium Tristan Scott: "I've listen to these biohackers. […] They eat animal based, they eat meat, but they would always be like, 'Well, there is one caveat. Methionine has been shown to be bad for aging […]'" Dr. Stephanie Seneff: "Can I talk about that there? Because I have a very good story for that." […] "I remember years ago reading about this methionine deficiency idea to try to live longer, and I was like, 'That is just so wild, so crazy. How can that possibly be true?' I was blown away by it. That just doesn't make any sense, because methionine is extremely important. It's like every protein that's made starts with methionine. It's how you start the protein synthesis. How could deficiency be a good thing? Just recently I had the idea because methionine of course is the source of methyl groups. This can get us into the deuterium big time." […] "It turns out the gut microbes are responsible for making this methyl CH₃, which has these three Hs that are not deuterium. They're like almost guaranteed not to be deuterium because of what the microbes do. So they become very important to the body, the CH₃ that's attached to the sulfur of the methionine amino acid. Then that CH₃ becomes the methyl groups that get distributed throughout your body, stuck onto your protein, stuck onto your DNA, your RNA. It's like thrown around everywhere in the body and they hold on to it. Then eventually it gets metabolized in place, like from the DNA, that methyl gets metabolized and turned into carbon dioxide and water within the mitochondria. "Those Hs get delivered to the mitochondria, Hs that are guaranteed not to be deuterium, and so that becomes very valuable to the body. It's actually storing all these methyls as a resource for when the mitochondria become toxic because they've got too much deuterium, they need to have a really good source of a guaranteed food that's going to be healthy, they can grab the methyls off the DNA. Eventually if they grab enough of them the DNA becomes deficient in methyls, and now you've got cancer, because that's how the clue for cancer, you know, many of the cancers are a consequence of hypomethylated DNA. The DNA has been losing its methyls, and that's like the cell is saying, 'Hey, my DNA is losing its methyls. We probably have a deuterium problem here.' It's like a signal that there's a deuterium problem, because it's had to steal the methyls from the DNA. "So they had this study on these rats and they fed them a synthetic diet. They were given amino acids that were produced in the laboratory. It was explained in the paper. So the rats were given all these equal appropriate amounts of all the different amino acids to eat. That's their food. It's very highly synthetic. It was made in the chemistry lab. So they gave the control group lots of methionine and then the treatment group low methionine. So that's your low methionine diet. They showed that the rats that got the low methionine diet lived longer and were healthier. So then they said, 'Well of course then methionine is bad.' Right? "The flaw is that that methionine that those rats ate was not guaranteed to have low deuterium in its methyl groups. It was made in a chemistry lab. So those methyl groups were not gold at all; they were just crap, so to speak. They were not healthy food. But on the other hand they had methionine so they weren't inspired to make methionine because it was already plenty. So they were basically misled into thinking that methionine was perfectly healthy, the way it would normally be if it had been made biologically. But because it was made in the chemistry lab it didn't have the low deuterium. So these rats are all saving all this methyl groups and being careful to keep track of them, but those methyls are no good, because they came from the synthetic laboratory instead of from a biological source." Dr. Stephanie Seneff with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 54:03–57:48 (posted 2023-12-05)

Drink only when you're thirsty, only as much water is necessary to kill your thirst. Water as an unpredictable source of deuterium. "If you don't know the deuterium content you have to limit the intake." Developing diabetes insipidus from excessive water drinking, making you even more thirsty Tristan Scott: "You said that you drink as little water as possible, and then when you do. . ." Dr. László Boros: "No. I only drink when I'm thirsty, […] and I drink as much as water is necessary to kill my thirst, and that's usually rain water below 125 PPM. It's very simple. […] It's deuterium depleted, but it's in the rain, kind of a good fall rain, 125 PPM or below. Tap water is 143 PPM to 155 PPM, most of the major cities. If it's coming from higher elevations, from for example the Colorado River, it may go down to 138 PPM. But it's still very high when you drink two or three liters of it a day. […] "I consider everything that you put in your body as a deuterium source, potentially. If you don't know the deuterium content you have to limit the intake. "The other problem is with excessive water drinking without salt is that osmolarity will drop in your blood. Osmolarity will drop in your brain cell, so you will actually have brain swelling that dismantles the hypophysis or the pituitary gland. It's actually locked into your sella turcica, which is a bony little compartment. That's where this organ, this pituitary gland, sits in. If you drink water excessively, this gland kind of expands in this bony capture, or it's capsizing this bony compartment called sella turcica […], and actually start compressing on ADH releasing cells, the antidiuretic hormone, and also sex hormone, and growth hormone, and thyroid hormone regulating cells, because they are all produced by the pituitary gland. So if those are swollen then your antidiuretic hormone is not helping you to preserve water, so you develop diabetes insipidus, and you have to drink more because you are more thirsty, simply because you are unable to salvage water through the actions of antidiuretic hormone, which prevents diuresis. It actually retains water from your primary filtrate in your kidneys, so you cannot regulate your own water homeostasis. "So you're actually exposed to an environmental, unpredictable deuterium source in the form of water. […] "Actually, you can actually die of water poison, you can die of brain swelling. […] Excessive water drinking without thirst is causing more harm that you can actually imagine. […] Your body has your thirst or any other natural signal. For example, if you're hungry you eat, if you're tired then you sleep, if you're thirsty then you drink. […] "Actually if you drink excessively, like let's say a liter of water half an hour, you're going to pee out 1.3 liters of water in the next four hours for sure, but it's gone in the next two hours practically. So it's useless. Your body is trying to get rid of it simply because it didn't need it. So you are constantly challenging your body to kind of overcome your behavioral patterns simply that are physiologically, biochemically totally against your own regulatory systems. Those are overdriven by media, by advertisements, and the list just goes on and on. That's our scientific position on this whole issue." […] "If you're thirsty, drink as much as is necessary. When we were kids we went out on these school trips, and I remember teachers telling us when we were like, 'Oh, I'm thirsty. I'm thirsty,' they said, 'Just don't drink. Don't drink. If you're still thirsty in five minutes, wait five minutes,'" Tristan: [laughs] Dr. László Boros: "'then you get one little sip. That's it.' And actually it was sufficient. Well, we were lean. We were not like as obese as nowadays these kids, unfortunately." Dr. László Boros with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 01:29:12–01:30:14, 01:31:40–01:36:26 & 01:37:33–01:38:12 (posted 2023-11-28)

Deuterium content of grain-fed sour cream or butter is higher than grass-fed by 26 PPM. Higher deuterium contributes to the chronic disease epidemic Dr. László Boros: "So we wrote a paper about this in Metabolomics which compares the metabolic and the disease state of the grass-fed and the grain-fed cows based on published data in the literature. It's in Metabolomics so if you want to read more about it." Tristan Scott: "That's the 'What to feed or what not to feed,' right?" Dr. László Boros: "Exactly. 'What to feed or what not to feed.'" Tristan Scott: "Yeah, yeah. I read that." […] Tristan Scott: "I had to ask the dairy question […]" Dr. László Boros: "Yeah of course. Very critical, very important question." Tristan Scott: "But it makes sense, right? If you have to grow obviously, I would imagine the deuterium content would be pretty high in some those. . . Dr. László Boros: "Yeah, yeah. We measure those. From your perspective, if you compare sour cream or butter from grass-fed cows compared to grain-fat cows if you compare to those. . ." Tristan Scott: "What, a 15 PPM difference? 20?" Dr. László Boros: "So you go from 110 to 136." Tristan Scott: "Wow." Dr. László Boros: "So yeah." Tristan Scott: "26. Wow. That's incredible." Dr. László Boros: "26 PPM. Yes. Listen, it's not a joke. I mean it's not just something just to walk by and say, 'Oh well, whatever.' It is significant and when it comes to human health and animal health, or just planetary health, or just practically chronic disease epidemics you have to take these into consideration unfortunately." Tristan Scott: "Yeah. 100%." Dr. László Boros with npub1yd2h2lrwchshvm46jq7auh65tjkxmgnapkavh7tjtqq07kknupxsa980tv @ 01:26:23–01:28:09 (posted 2023-11-28)

Why could celiac be a result of glyphosate? Glyphosate is used to dessicate wheat for harvest wheat in US & Canada. Lactobacillus in the gut aids digestion of gluten. Glyphosate kills lactobacillus Aastha Jain Simes: "Why could celiac be a result of glyphosate?" Dr. Stephanie Seneff: "Yeah, that's a very interesting one. I wrote a whole paper on that together with Anthony Samsel. I was very interested in it and I definitely think that it's the primary cause of the epidemic that we're seeing in gluten intolerance. It's amazing how it's kind of shot up out of nowhere. I started noticing, I can remember maybe 10 years ago all these gluten-free foods showing up, and sections of the grocery store devoted to gluten-free. "I was puzzled by that. But then once I realized that glyphosate is sprayed on the wheat right before harvest quite often here in the United States and especially in Canada where it can get cold. They want to beat the frost, they can accelerate the maturation to produce seed and they can synchronize the harvest so that they can get a higher yield if they spray the crop with glyphosate shortly before harvest. "And then of course when the glyphosate goes into the seed and so you get especially high levels of glyphosate in the wheat germ, which is a very healthy food normally, but the highest levels are showing up in the wheat germ because that's where the glyphosate is going. It gets into the tissues of the plants; you can't wash it off. "Lactobacillus is a microbe in the gut that's very important for the infant for digesting milk actually, but also gluten. That microbe specializes in helping the host to digest proteins that contain a lot of proline, and both casein and gluten contain a lot of proline. Proline is a special amino acid that uniquely requires special enzymes to break it apart from the other amino acids in the protein, and the lactobacillus provide those enzymes to the host. So that's a very fancy collaboration between the bug and the host to deal with the digestion of the wheat. And I think part of the problem is that lactobacillus is being killed off by the glyphosate, the wheat is not being adequately digested, and these short peptides containing proline are sticking around. "And when the immune cells see a peptide sequence that's a foreign protein they get upset, so the immune cells produce antibodies to that. And then it turns out there's this mechanism called molecular mimicry where the antibody gets confused and sees a human protein that's similar and starts attacking that instead. And transglutaminase in fact is the particular protein that gets attacked by an autoimmune disease called celiac disease, which is a very specific form of gluten intolerance. And celiac disease in this paper we showed a plot that showed that celiac disease was going up in prevalence over time in the United States exactly in step with the rise in glyphosate usage on wheat, not corn and soy, but wheat, which was a different curve, but it matched much better with the gluten intolerance than the usage on corn and soy, which makes sense because it's wheat that's the problem. "So I really feel pretty confident that glyphosate is the primary cause of the epidemic that we're seeing in gluten intolerance." Dr. Stephanie Seneff with Aastha Jain Simes @ 11:05%%14:10 (posted 2024-05-30)

In the first trimester, a female fetus will cause nausea, vomiting, & fasting, effectively keeping mom in ketosis to limit deuterium for its developing follicles. Effect of deuterium consumption in adult males vs females Dr. László Boros: "Fertility is very important, because it's simply it seems like the oocyte, the female reproductive system locks in all the follicles in the female reproductive organ. They have about 400,000 follicles in the ovaries, and about 400–500 of them become eventually ruptured or matures to be fertilized with a sperm. "And it happens in the female babies it happens in pregnancy. By the third month you have the baby's ovaries with all the follicles developed. After that, they go into a dormant state. […] They are surrounded by follicular cells, so they don't really get involved in metabolism, and it doesn't matter what you eat. "While in the first trimester, you may throw up, you may have nauseation. […] So […] you fast. You practically keep yourself in ketosis, you know it or not, but practically that's what your body is trying to do. If you eat too much you throw up, simply because your baby is trying to limit deuterium for these follicles as much as possible. So that's locked in in life. "It's different in males because they produce sperm constantly. Their sperm's DNA or chromosome deuterium content is different from that of the females. The females can eat anything: their oocyte, the haploid DNA or chromosomes, they don't gain deuterium. "But the sperm would. So eventually in nature we know that the males that go to a successful mating fight, meaning that they are lowest in the deuterium, because their nanomotors and muscles and all those abilities are the best in that particular male generation, they will have the chance to mate. So nature still kind of depletes deuterium in the sperm, too, but it's a different natural scenario. "And we are exploring all these marvels and beauties of nature, and we do our interpretation, means that we interpret those findings from the point of view of deuterium. So practically, it's almost like you can explain all kind of weird stuff that happens in nature. You may not understand it from just looking at it, but once you talk as a deutenomicist, or once you apply deutenomics to those particular biological principles, you gain a little better insight of why things happen, in what order, and for what reason." Dr. László Boros with Sarah Kleiner @ 31:06–34:38 (posted 2022-08-10)