Serendipitous conversation at a bar in Bregenz in 2008 leads to discovery of how NO is made in skin from UV. Seasonal variations in blood pressure due to UV on skin
Professor Richard Weller: "[…] But problem solving those experiments, we showed that the skin contains large stores of nitrogen oxides: nitrate, nitrite, nitrosophiles. And at the time, I did not know what that meant. It was thought that nitrate was an inert end product of nitric oxide oxidation. It was thought it did nothing and was peed out. But I found all this stuff in the skin for no obvious cause. I sent it off to the JIT, which was the top dermatology journal. I sent the usual cover letter, 'Groundbreaking science. You're so lucky to get this. Brilliant stuff. You should really take it,' whilst thinking to myself, 'I don't know what this means. I have no idea. I think this is rather odd.' Anyway, they accepted the paper, much to my surprise, because I wouldn't have done so. It's actually turned out to be a really important paper.
[…]
"So what Martin showed, in this methods paper that nobody read, was that when you shine UV at nitrate in the presence of thiols, SH groups, you get a photochemical reduction of nitrate to nitrite. […]
"[At the] NO group […] meeting in 2008 […] in Bregenz […] at the bar after a day of science, I was saying to Martin and my friends around the table, 'I've discovered these huge nitrate stores in the skin. I have no idea what it means. I've managed to publish it. Can't understand why. What does it mean?' And Martin said, 'I've written this paper three years ago that nobody has read. We showed that UV releases NO from nitrate in the presence of thiols.' And I went, 'Oh my God, UV hits the skin, the skin's got lots of thiols, you know, it's got all these keratins containing thiols in the skin. And it's got lots of nitrate. You've got the three ingredients that make NO.' And talking over the bar, I could remember from medical school days that in sunny times of year, blood pressure is lower. Could this account for those seasonal variations in blood pressure? […]
"So we quickly published this hypothesis paper in the European Heart Journal saying we think this might be happening. We think that sunlight hits the skin, we think that it photoreleases these nitric oxide stores to the circulation, which lowers blood pressure. And we then set out to try and confirm it."
Professor Richard Weller @ 16:18–17:14 & 25:17–28:39 (posted 2025-10-11)
Why would I get fat?
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I am not a doctor. I do not give health or medical advice. Instead, I excerpt what others say.
UV in sunlight hits the skin, releases NO, which moves into circulation, which dilates arteries, which lowers blood pressure, so you don't get a heart attack or stroke, and you live longer. Dermatologists don't care
Professor Richard Weller: "We then shone UV at the arm. And we either shone UV at the arm so rays hit it, or we shone UV at the arm but it was covered with a foil blanket so the temperature rises but UV doesn't hit the skin. And what we showed was that when you irradiate the forearm it causes vasodilation. So ultraviolet in man is an arterial vasodilator, and the sham arm there was no vasodilation. So UV in man is a direct vasodilator.
"Blood pressure is a function of total peripheral resistance and cardiac output. So you multiply what the heart cardiac output is by the peripheral resistance (and the more constricted vessels are the greater the resistance), and the function of those two gives you blood pressure. So we then stood people in UV cabinets or we lay people under full-length UV lamps, and we showed that shining UV at people lowers blood pressure. The sham irradiation, covered with the foil blanket so that the temperature goes up and not the rays, there's a fall in blood pressure while the lamps are on because you get warm. But as soon as the lamps are off, the sham irradiation returns to normal, but the actively irradiated stays down.
"And then you have a rise in circulating nitric oxide in the irradiated group and a fall in nitrate. So sunlight hits the skin, releases NO, which moves into the circulation, which dilates arteries, which lowers blood pressure, so you don't get a heart attack or stroke, and you live longer. That's great.
"So that was super. Of absolutely zero interest to dermatologists. Not interested at all. Couldn't be. They really don't care."
Professor Richard Weller @ 32:01–34:06 (posted 2025-10-11)
In UK, summer blood pressure is significantly lower than winter, as great an effect as a drug. If you're a male living in Scotland, you are 30% more likely to drop dead in a week in January than a week in August. Vitamin D supplementation has no effect on myocardial infarctions, no effect on strokes, and no effect on cancer deaths
Professor Richard Weller: "When you analyze blood pressure by the month of the year in which the blood pressure was taken, we see there's a huge seasonal variation in blood pressure in the UK. So in summer blood pressure is significantly lower than winter. And in fact the effect of season is as great as the effect of a drug in lowering blood pressure. So what this might suggest to you is that sunnier countries, or within a country, sunnier times of the year correlate with lower blood pressure. […] The more UV that falls the lower cardiovascular disease incidence, which is a sequela of high blood pressure. So that's observational data.
"The next bit of observational data is really looking at vitamin D. So UVB formation is responsible for vitamin D synthesis in man. So blood vitamin D levels are a great indicator, a biomarker for how much sunlight and specifically UVB you've had. And we know that people with lower measured vitamin D levels are more likely to have hypertension, more likely to have cardiovascular disease, more likely to die of stroke, and in fact more likely to die of any cause whatsoever. So that's observational data.
"The problem is when you carry out interventional studies, when you enter people into randomized placebo controls, double-blinded trials of vitamin D supplementation, it does pretty much nothing. So this is a meta-analysis, a combined analysis of multiple trials of vitamin D supplementation published in the Lancet, gosh, 12 years ago now. Giving people vitamin D has no effect on myocardial infarctions, no effect on strokes, and no effect on cancer deaths. And the biggest study of all was completed about five or six years ago in America. So this was is a study called the VITAL Study funded by the NIH in America. 25,000 Americans randomized, half to get vitamin D supplements for five years, half to get placebo. The results have been published largely in the New England Journal, and the results are broadly negative, negative, negative, negative. Some possible effects on autoimmune disease. So that was 25,000 people for five years. The Australians ran a smaller study, 21,000 people for five years. Half get vitamin D, half get placebo. Results are negative, negative, negative, negative. So, it's not the vitamin D.
"And this is an editorial from the New England Journal from 2022, four years ago now, saying, 'Adding those findings to previous reports, etc., etc., people should stop taking vitamin D supplements to prevent major diseases or extend life.' So clinical trials confirm it's not the vitamin D. So vitamin D is a biomarker of a sunlight exposure and it prevents rickets in children. You know it has some benefits, prevention of rickets being the main one. […]
"If you're a male living in Scotland, you are 30% more likely to drop dead in a week in January than a week in August. Huge, huge. We've just passed the equinox, heading the wrong way. Time of year when I start to get a bit antsy. You know, summer's fine. Am I going to survive another winter? You know, the data is pretty serious. We know that vitamin D accounts prevention of rickets, but what about the rest? And that's really the question that we're facing now. So this is observational data and the vitamin D debunked by trial data: limited benefits."
Professor Richard Weller @ 10:50–15:12 (posted 2025-10-11)
"I regard consciousness as most fundamental." — Max Planck. Consciousness, energy and matter. _The Case Against Reality_
Martin Picard, PhD: "Max Planck, who is a quantum physicist, at the end of his career he wrote at length about this and he ended up saying, 'I regard consciousness as most fundamental. Matter and everything else just emerges from consciousness, from this deeper level.' David Bowman, also a physicist, kind of arrived at the same conclusion. Einstein said similar things. So there's a lot of people who've thought about energy, who've thought about matter, and at the end of their lives, they're like, 'Shit, this that doesn't make. . . there's something else. There's a deeper underlying layer of reality.'
"So my perspective on this is I don't know what the truth is, but I suspect that there's kind of this underlying current and let's call it consciousness. Some people might want to call it God. Some people might want to call it, you know, energy and like dark energy or whatever. […] So, there's the force or the force of consciousness, let's say, that is flowing, that's just energy. What energy does is it naturally seeks ways to transform itself or to move and to flow. This is like a fundamental property of of energy in its different forms. Energy wants to flow, wants to be transformed. So maybe there's an underlying current of consciousness.
[…]
"So I think it's a worthwhile hypothesis, and then it brings us to think from first principles about the nature of each of our movement, but also to see ourselves as movements, and then an energetic movement. So, we're always in flux, always changing, and there's some kind of structured or some, you know, an eddy looks like another eddy, but there's a lot of differences. The same way human beings look, you know, a lot of features we share, but we're also very different. And we have genetically identical human beings, you know, monozygotic twins that are so different and personalities and their likes and dislikes. Where does this come from? I don't know. But maybe there's a deeper layer of organization that precedes the molecular structure of our genomes and other things.
"So we can't disprove this, in the same way that we cannot prove that the materialist or the physicalist viewpoint is superior. So at this point there's been very good arguments made by Don Hoffman, who wrote this beautiful book _The Case Against Reality_, who makes the same point that matter is not most fundamental, despite what your senses are tricking you into believing. Matter is not most fundamental. There's another layer, and then you're an expression of that layer, and your own conscious experience is in a way this movement of consciousness or energy that is experiencing itself. And so this leads to really interesting questions and hypothesis which I develop in the book that I'm writing called _Energy_."
Martin Picard, PhD with Thomas P Seager, PhD @ 45:35–46:55 & 48:06–50:17 (posted 2025-09-19)
All sex hormones originate in the mitochondria. Mental health disorders as metabolic disorders. You are not a molecular machine; your brain is not broken. You are an energetic process fueled by your mitochondria
Thomas P Seager, PhD: "But what I picked up along the way is that mitochondria are the site at which all sex hormones originate. So whether it's testosterone, or even cortisol, or pregnenolone, which is a sex steroid synthesized on the inner mitochondrial membrane. If your mitochondria are not in good shape, it's no wonder you don't feel like yourself. You might lose your motivation. You might lose that zest for life that gets you up off the couch. And then when the mitochondria are restored, you can literally feel like you're a different person."
Martin Picard, PhD: "I think that's quite possible. At at this point, I would say it's a partially supported theory, right, the mitochondrial theory of mental health, or mental health disorders as metabolic disorders. I think there's a lot of strong evidence that says this is correct. If you don't feel well, right, then you don't feel like yourself, and you feel terribly depressed that you want to die. Or you have bipolar disease that you fluctuate between states of mania and states of deep depression, or you see, you hear things that other people don't hear, and you have some dissociative experiences and schizophrenia.
"All of this is not because your brain is broken. Your body is not broken. You're not a molecular machine. You are an energetic process fueled by your mitochondria. And if energy isn't flowing properly, you as a person, your energetic self changes.
"And when that happens, you know, this you might be the most first principle understanding what disease is. Right? Dis-ease, when you're not at ease, this can happen probably very quickly because your energy isn't flowing properly. And there's some example, historical example. I learned this when I was in graduate school. I was learning to study mitochondria, mitochondrial respiration, right? One major way in which mitochondria do all of these things, including making hormones, you know, the sex hormones that give the female body the ability to conceive, to carry new life, right? Progesterone, estrogen, those are made in the mitochondria. This is amazing. And testosterone determines whether you get a penis or not during embryogenesis. Testosterone is made in your mitochondria. These hormones are the basis for the survival of our species. And for some reason that nobody understands, their synthesis was converged in the same organelle, the same cellular site that's responsible for keeping the lights on and making decisions about cell life and cell death. So I think there's a profound connection there between energetics and survival of the species, and mitochondria are kind of the hub for this."
Martin Picard, PhD with Thomas P Seager, PhD @ 09:07%%11:58 (posted 2025-09-19)
Gaining insights into autism from studying melanin migration defects in Siamese cats. Blue light liberates vitamin A, which then destroys melanin sheets
Dr. Anastasia Bendebury: "Is the alpha wave signal in the thalamus different in people that have sensory defects?"
Dr. Jack Kruse: "Of course! I mean the perfect example of that is people with autism. Think about what autism functionally is: it's a neural melanin migration problem that is a transgenerational problem that happens between the mother and the father.
"And most people don't even know this, but Siamese cats […] lay this out. If you go and look at all Siamese cats you'll notice they all have blue eyes. OK? And the funny thing is they have a lot of problems with their eyes, meaning sometimes they get turned in, they're all kind of crazy. The reason for that it turns out that the melanin that's in their neural tracts is really abnormal so it affects migration. […]
"Melanin controls migratory patterns in neuroectoderm, and it turns out it does this through vitamin A. Vitamin A has huge effects. Well, guess what? The non-visual photoreceptor system in the brain, which melanin is part of, so is cholesterol, so is melanopsin, so is neuropsin, […] in humans there it's a weak covalent bond to vitamin A. So the reason why blue light is really bad, it liberates vitamin A, and what does that do? That destroys melanin sheets anywhere they are in your body. What happens then? You get neuromigratory pattern problems. This is the reason why kids with autism actually show what I call a regressive evolution. They go back to being like a monkey who can't talk, because the melanin is not there.
"Just think about when a baby comes out of your vagina. Can the baby talk and walk and run around? The answer is no. Why? Because it's neuromelanin has not developed in its head yet. Well guess what? That system is broken in kids with autism in their sensory relays. And guess what? Are all those studies done in the ENT literature for the calyx of Held, is all that stuff done in the central retinal pathways? Yeah! It's all there! But nobody's putting it together. But guess what?
"Why have I had a Siamese cat ever since I'm 15 or 20 years old? Because I learned about melanin a long time ago. I've been fascinated by it since I'm a little boy. But I didn't know what melanin really did until I got to be about 40 years old. Then when I figured it out, I'm like, 'This is the fucking greatest story never told.'
"And when did I first tell that story, in total, of really what it means? I told it to Rick Rubin and Huberman in 10 hours, and left both of their jaws on the ground. This story is the greatest story ever told. Anybody who's interested in biology, anybody who's interested in evolution, has a duty to themselves to listen to it. This will shake your foundations.
"But I promise you this, and I swear on my life I'm right about this. You'll become a much more curious mammal after you listen to this and listen to this perspective. You will become better interviewers, because the future scientists that you're going to have on after me, you're going to say, 'Wait a minute. We need to put this through this lens. What is the effect of this on endogenous light production? How does that change the hydrogen bonding network in water? And then how does that change the paramagnetism of free radical signaling in us?' Is that fundamentally what free radicals are all about, it's about magnetic flux? Of course it is! Anything that makes an EPR signal, there's a free radical, because it has an unpaired electron. Oh shit, look at that: we're back to that goddamn physics story again.
"Look, this is a fabulous story, and I tried to tell you that I got tuned into this fabulous story through Albert Szent-Györgyi and Becker. And I jumped down this rabbit hole and I don't want to come out of it. I want to blow up the paradigm that created me."
Dr. Jack Kruse with Dr. Anastasia Bendebury & Dr. Michael Shilo DeLay @ 02:17:18–02:21:32
The World Health Organization is a criminal organization. It needs to end. Switzerland is complicit in global acts of terrorism. Drug industry activism branded as "Public Health"
Dr. David E. Martin: "The World Health Organization is a criminal organization and we need to call it what it is. It started off in the beginning of the last century as the Opium Board. And I want you to just kind of sit with that. The Permanent Opium Board. That's what the World Health Organization was before it rebranded. Now if that sounds like a health organization, you're already delusional. What that was was the British East India Company legacy playing itself forward, and it was actually, as you know, after the Chinese disputes around the opium trade in the 1800s, where we decided to actually create a criminal cabal, not unlike OPEC, but it was for heroin and opium. Call it what it is. These are criminals.
"And it turns out that they decided to domicile in Switzerland because they actually wanted to get immunity from prosecution, and Switzerland had neutrality laws that made it most favorable. And when they wrote their charter they said they were immune from criminal behavior. So giant shock. It's a criminal organization. It's like the mob writing its own constitution going, 'Well, we're going to be the mob, we're going to write our own constitution, and you're not going to be able to investigate us regardless of what we do, because we said so.' And the rest of the world just nods their head and goes, 'Oh, OK, OK, yeah, and you said so.'
"At no point by the way is any of what I just said legal, but in in fact it is now law. Switzerland now defends the World Health Organization, and a criminal organization is running inside of Switzerland. And the Swiss are actually complicit in global acts of terrorism by virtue of shielding and harboring terrorists.
"I think we should actually start calling for Switzerland to be declared a terrorist state. Why not? We actually talk about state-sponsored terror everywhere else; why is it that we don't talk about state-sponsored terror in Switzerland? And why shouldn't we? Because they're harboring one of the largest lethal organizations on earth, the religion of that organization which leads to global terror is a religion called, allegedly, 'public health.' But 'public health' is neither public nor health. It is the advancement of drug industry activism and drug industry interests, and it is that sole purpose for which the criminal organization and the criminal cartel is established.
"So, let's start a campaign where we actually label Switzerland what it is: the state sponsor of terror which has killed more people than all of the Islamic movements, all of the craziness that's come out of other extremist programs, all of those things combined. The World Health Organization leads in fatality. So, state-sponsored terror: you got it. Switzerland, the harbor for the state-sponsored terror: absolutely. And wouldn't it be fun for us to actually see people start to hold accountability where it belongs.
"Because when it was established in 1953, remember that this was an organization that was put in place specifically to launder private sector donations into the rubric of a public, state-sanctioned version of the advancement of medical technologies. And what we have to understand is that that decision in 1953 allowed organizations like the Gates Foundation, like Gavi, like all of the UN-affiliated organizations around health, it allowed them to operate with impunity, because they can actually conduct clinical trials and kill people without any consequence. There is no standard for ___ in any of the programs that they advance as long as they can convince themselves that there is a 'world at risk.'
"Well, it turns out that if you're making the pathogens, and then you're deploying those pathogens, you can create risk wherever you want it. And the great news is because of the articulation of the history and the message of the World Health Organization, beginning ironically about a year ago, when a number of Europeans got together and invited me to do a tour of European countries where I made this presentation several times, we are succeeding in the undermining of the resolve not only of the Treaty, but I'm starting to see cracks where a number of people are starting to question whether the World Health Organization is actually a legal operation in the first place. And I want to see those cracks open up into full fissures and I want the thing to fall apart, because it has to. Because it is a criminal institution and we need to see it end."
Dr. David E. Martin with Brian Rose @ 53:46–58:23 (posted 2024-07-03) https://rumble.com/v55af7l-dr-david-e-martin-ww3-global-catastrophe-over-2-billion-will-suffer-gruesom.html?start=3226
Human photosynthesis is driven by melanin. What melanin does
Dr. Jack Kruse: "Human photosynthesis (actually all animal photosynthesis) is driven by melanin.
[…]
"Hemoglobin and chlorophyll were the two main semiconductors that life used prior to the Cambrian explosion. After the Cambrian explosion, which was 650 million years ago, a third semiconductor showed up very, very quickly and kind of became the dominant player, […] and the chemical is melanin.
[…]
"I can easily elucidate for you why melanin is important: it creates hydrogen and electrons and oxygen. That's what it fundamentally does in the cell. […] A cell makes a DC electric current by charge separating water utilizing melanin to do so.
[…]
"The force carrier for electromagnetic force is a photon. That's light, OK? Light liberates electrons from water. OK? The same story that happens in photosynthesis, OK, except it's much more efficient when in melanin is involved. OK? In photosynthesis, only two electrons are popped out. In melanin biology, four electrons are popped out plus more hydrogen is made. So you make a bigger electric current. […] The difference between hemoglobin and chlorophyll, there's 12 electrons. OK? That's the difference between simple and complex life. It turns out that melanin made more complex life even more complex because it allowed more energy production inside the cell after the Cambrian explosion. Therefore the things that we should see in life as we go further along say the history of evolution is we should see higher levels of redox chemistry. We should also see higher levels of DC electric current. We should see increased utilization of light in much more complex fashions, meaning non-linear optics should be a part of the system.
[…]
"The gene product that makes melanin is called POMC, proopiomelanocortin. It only gets translated or turned on by UV light. OK? So one of the peptides, the neuropeptides that's made from this besides α MSH that makes melanin, you know what it's called beta endorphin. Do you know what that means? Nature made you to be built to have a certain quantized amount of an opiate, to be outside.
[…]
"The mitochondria is an electromagnetic producer of light, similar to the sun, inside of every cell that actually is the composer that is directing all the boxcars in biochemistry to do this, and it works on redox signaling and light frequencies. And is that the reason why melanin controls the endogenous life story that's created inside us? Is that the reason why tryptophan, serotonin, melatonin, and leptin all have emission spectrums between 200 and 400 nanometer light that doesn't come from the sun, because maybe we make the light inside of us.
[…]
"What melanin is functionally doing, and why melanin is the color that it is, why certain semiconductors are the color they are, and really what melanin is functionally doing, it's actually creating a kaleidoscope inside of us that control everything in us. And when you actually look fundamentally at a cell, we have 100,000 biochemical reactions in one second. The only thing, when you just think about it, that can control that is all the different spectral frequencies that go between 200 and 1100 nanometers.
[…]
"It turns out that melanin and different proteins in different parts of the cell are emitting and absorbing different frequencies. So that means that, for example, the neighborhood in and around cytochrome C oxidase is loaded with infrared A light, because that's what its absorption spectrum is around. But the same thing is not true around cytochrome 2, where it's flavins and it's much more in the 400–500 range. And then it's also not true at cytochrome 1, because that's where it's in the UVA range."
Dr. Jack Kruse with Dr. Anastasia Bendebury & Dr. Michael Shilo DeLay @ 11:28–11:33, 10:25–10:54, 17:42–18:13, 19:07–20:36, 01:08:05–01:08:35, 01:26:20–01:26:58, 01:35:02–01:35:38 & 01:42:36–01:43:06
Why build a solar callus. How to build one
Dr. Jack Kruse: "I want Bill to learn how to turn on the solar callus in his body. […] Solar callus, the way I like to describe it, […] you go in the Louis Vuitton store with your wife. She looks at the shoes and she goes, 'Oh, baby, these hurt my feet.' And then Rick turns around and said, 'Baby, you get those shoes, wear them five times around the house, and you'll be fine.'
"You know how to break shoes in, but we don't know how to break our skin in. So when you're a white boy like me, actually all three of us, we all have skin that Fitzpatrick I or II from high latitude. What you need to know is the program's still in you. You can still make melanin, but you have to turn POMC on, […] proopiomelanocortin. […] That's the basis of melanin story that's there for α MSH.
"The key there is first thing you want to do to build it up, eat a lot of shellfish. Why? Because the chitin, the exoskeleton in that has a lot of chromophores that help the skin. OK?"
Rick Rubin: "Is it in anything else or only in shellfish?"
Dr. Jack Kruse: "Oh, no, it's in other things like for example, tomatoes. OK? You'll also find it in some fruits. I'm trying to think of a good one. Macadamia nuts. […]"
Rick Rubin: "I like macadamia nuts as a nut."
Dr. Jack Kruse: "I do too because they have high DHA.
"The second step is then I want you to think about the circadian biology of the sun. In the morning, this red is really powerful. There's no UV. So you get a lot of red light. Red light preconditions the skin to make more UV, in other words, it helps everything in your skin, the fibroblast, the collagen, the water, it energizes it.
"And as soon as the UV comes out, the POMC that's buried in your skin turns on and you begin to make melanin.
"So melanin biology becomes upregulated because of those three things that happen. You're putting substrates in the body, which are basically proteins that allow you to assimilate light and meaning they have an absorption factor. Then you're using red light to get all the collagen ready. And then when the UVA starts, that's the stimulus to turn on α MSH.
"Then slowly, if you do this over four to six weeks, you will create your own melanin in your skin. That's the story, the idea that I got with the African-American lady with vitaligo. That's exactly what I did on her to actually stimulate it, and I wanted to know how fast it can happen. It happens quick. And then the flip side of that story is what Rick brought in part one and part two when he told us about when I go from low latitude to high latitude, I lose it pretty fast, too. […]
Rick Rubin: "I have a friend who I knew back in my old life who saw me and he said, 'I didn't know you could get tan, based on how white your skin had always was. I didn't know it was possible for you to have any tans.'"
Dr. Jack Kruse: "And you know why I'm glad he just said that? Because Bill, that's the teaching case. Does a high latitude northern European, who's got Fitzpatrick type I skin, has Rick proven. . ."
Rick Rubin: "With blue eyes."
Dr. Jack Kruse: ". . .that what I just told you, with blue eyes, has Rick just proven, as the hippo and lion, he knows how to do it now? Not only that, he also is so in tune, he's like, 'Jack, when I fly home, I actually know that I lose it.' And guess what? I don't have to talk to Rick anymore. He knows. I don't have to tell him again."
Dr. Jack Kruse & Bill Gifford with Rick Rubin @ 01:56:37–02:00:36 (posted 2024-03-13) https://youtu.be/watch?v=EHe78j9UrMI&t=6997
We're designed to eat the fish, not the pills. DHA at the sn-2 position
Max Gotzler: "I know you're also not a big fan of pills and supplements, but would you say to fish oil pills with DHA in them? Not a good idea?"
Dr. Jack Kruse: "No. And the reason I'm not a fan, it gets into the details. When it comes to quantum biology, you have to understand within the eye and the brain, DHA gets put into it in a very specific way. And it's called the sn-2 position, and I'll explain it to you very simply.
"All fats in the body have three carbons. That's the glycerol backbone. Sn-2 means the middle one. So for DHA to work optimally within the brain to have that good π electron cloud, it needs to be in the sn-2 position. So when you have pills that are created by man from fish, most of it is in sn-1 and sn-3. That means it's effectively useless.
"What's one of the things that food guys like you know? That polyunsaturated fats are really bad for us. They make a lot of inflammation.
"So here you think the fish oil is good, but remember the fish oil is a polyunsaturated fat. So if it's in sn-1 and sn-3, effectively that can make your highly sensitive CRP or inflammation go through the roof. No bueno.
"See the nice thing is, the way it's designed to work in nature, fish eat algae, algae do photosynthesis, and then the fish turns the DHA that's in the algae into the sn-2 position. We're designed to eat the fish, not the pills."
Dr. Jack Kruse with Max Gotzler @ 33:22–34:53 (posted 2017-02-14) 
Die Flowgrade Show mit Max Gotzler: #035: Skiing In Underwear Or How To Hack Your Mitochondria With Dr. Jack Kruse
Find the Show Notes at www.flowgrade.de/jackkruse In this episode with brilliant neurosurgeon and biohacking mitochondriac, Dr. Jack Kruse, you wil...
To maintain mental health, never miss the sunrise. Be like the Sphinx. Deprogramming the propaganda of Rockefeller medicine
Dan Lawson: "Is there anything specifically, if you were to tell somebody, or I don't know, maybe I guess something that would be one of the primary things for them to maintain their mental health. Obviously, you'd like to be in the tropics to get into the nature that their body. . ."
Dr. Jack Kruse: "No. It's simpler than that. There's one thing that I say at the end of every podcast when people ask, 'What is the number one way to be healthy across the board, whether it's mental health or not?'
"Never miss the sunrise the rest of your life. Always, no matter where you are on the planet, go outside and see the sunrise. It doesn't matter if you see it. Just let your eyes be out in nature to feel the color temperature and the frequency. If you do that, that's 80% of the ballgame."
Dan Lawson: "OK. That's huge. I mean, that's made a profound impact on me. It's wild when I talk to people about your work, or I give them either directions to the different interviews that you've done or the work that you have on your blog and different things, is they're shocked by how much different they feel in a way that they've never done. Because these things, like again, they've never been exposed to these things."
Dr. Jack Kruse: "They've been exposed to the propaganda. They've been exposed to the propaganda of Rockefeller medicine. And you know what? It takes years of deprogramming. Look, you think it's easy to tell people, 'Look, you've been brainwashed by the people that you trusted.'? I mean, the reason that my message resonates right now, is think about when we just came through with covid. Everybody knows they were full of shit. So guess what?
"Now everybody's like, 'OK, Jack is telling me that the Sphinx was put out there at the 28th latitude, looking to the east, with all grounded. And that's an ancient method that, well, that's exactly what you need to do when you have the diseases you want to reverse.' That's all you need to do. Start there."
Dr. Jack Kruse with Dan Lawson @ 56:20–58:06 (posted 2025-09-10) 

iVoox
Exposing the Lie of Hormonal Imbalance: Dr. Jack Kruse and the Biophysics of Optimal Mental Health - Smuggling Hope - Podcast on iVoox
Listen to this episode of Smuggling Hope for free on iVoox. In this episode, we talk to neurosurgeon and health visionary Dr. Jack Kruse. His work ...
You cannot get well in the same environment that got you sick if your mental disorder is severe. The brain changes its wiring in response to the environment
Dan Lawson: "What is your advice for people, besides just being able to get out every six weeks. Like it'd be nice to go to Aruba; I'd like to do that. But in Buffalo, you know, where hope goes to die sometimes, I'm just wondering what your advice is on how to maintain the right types of light in an environment where the sun doesn't shine a lot."
Dr. Jack Kruse: "[…] It depends on the severity of the situation. Most people who already have seasonal affective disorder or bipolar disorder, they have a pretty severe problem. So it's incumbent upon them, if they realize that they want a reversal of disease, they're not a tree. They need to pick up and leave Buffalo. Why? Because that's a disease that's not going to get better there. It's the same thing that's true in Norway and Sweden and Finland, who have the highest incidence of prevalence of these diseases.
"Now, once you fix the problem, can you go back to those places and watch the Bills lose more Super Bowls? Yep. You can do that.
"But what I think people need to really, really embrace is that people that just have bad wounds, say, in the wintertime, those are the people that I think can take the trip to Aruba and magically they'll say, 'Wow, I feel better.' People we're talking about are the people that have a hardcore mental disorders.
"You cannot get well in the same environment that got you sick. This is a very, very counterintuitive and hardcore message for people to hear because one of the things I want to make sure you understand and the audience understands is the brain responds to the environment, then it changes its wiring. So what does that mean?
"If you stay in that environment, the wiring is not going to change. So what you need to change is the wiring, and it's the light that fundamentally does it. So if you can't get that light in an environment, that's why you have a duty to yourself to say, 'OK, it's time to go.'
"Now, here's the beauty of the human brain. When you put it back in the environment, it will respond to the new light signals that you give it and it will unwire the bullshit so that you can rewire back to your full potential."
Dr. Jack Kruse with Dan Lawson @ 21:15–23:25 (posted 2025-09-10) 

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Exposing the Lie of Hormonal Imbalance: Dr. Jack Kruse and the Biophysics of Optimal Mental Health - Smuggling Hope - Podcast on iVoox
Listen to this episode of Smuggling Hope for free on iVoox. In this episode, we talk to neurosurgeon and health visionary Dr. Jack Kruse. His work ...
The environments that lead to mental disorders. The defect is not in you; the defect is in the environment. The sun is the compound pharmacy that your frontal lobes need
Dr. Jack Kruse: "The drugs that they use are really not effective at treating these disorders. Mental disorders really have become more common in the last 50 years. Why? Because we now live in an artificial environment. Most people are addicted to tech screens, they're inside, they're not outside, and people don't realize how this has had a huge effect on how the brain grows the first 28 years of life. And it's gotten so bad in the last 50 years that we are now seeing kids that are born with high heteroplasmy in their frontal lobes and they get mental disorders right off the bat. The most common ones are ADHD and OCD, which is obsessive compulsive disorder. Those are the ones that are the most common.
"If you talk to, I think, most kids under 24, the number (the last time I saw) is over 90% of those kids have been offered a prescription for Ritalin by a pediatrician. That's crazy. That wasn't like that when I was a kid. When I was a kid, I was never offered that prescription. But I can tell you that my son and my daughter, they were offered those prescriptions by pediatricians, and that tells you a couple of things. It could mean the doctors are crazy now, or the patients are more apt to have mental disorder because the environment has changed. That's the key thing.
"Big Pharma wants you all to believe is that the defect is in you. What am I here to tell you? It's exactly the opposite. The defect is actually in the environment that we create. What does that do? It makes the changes in the neurologic system that give you mental illness. Then through marketing, through propaganda, Big Pharma has you believe that the defect is in you, and that's just not the case.
[…]
"The neurochemicals in the brain are made […] from aromatic amino acids. And what you need to know, when I say the word aromatic amino acids, […] I want you to understand what it means. It means it absorbs UV light. […] Everybody who gets SAD, everybody who gets depression, what do they tend to not have? UV light. So guess what? You don't have a 'chemical imbalance.' You have a light imbalance because you can't make the chemicals because the light is not in your environment.
[…]
"If you put somebody who's human, even with severe mental disorder, and you put them in nature, you can see massive improvements. Are there papers now in the literature that actually say that? The answer is yes. Obviously, if somebody's horribly bipolar and you put them out in nature in the tropics, they'll get better, […] slightly better, but you may not reverse the disease unless you do everything right. […]
"You have screens, you have TVs, you have subway ads telling you, 'Hey, take Zoloft, take Prozac, this is what you really need.' And when we tell people, 'Hey, the sun is basically a cornucopia of a compound pharmacy that your frontal lobes need,' that message doesn't resonate because […] they've been exposed to the propaganda. They've been exposed to the propaganda of Rockefeller medicine. And you know what? It takes years of deprogramming."
Dr. Jack Kruse with Dan Lawson @ 16:23–18:06, 44:40–45:15, 18:06–18:31, 19:10–19:30 & 57:29–57:37 (posted 2025-09-10) 

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Lipid nanoparticles were known to be toxic when they were created. Pseudouridine is an active cancer promoter, known since 2018. Both Pfizer and Moderna willfully killed human beings
Dr. David E. Martin: "In the shots that were used, for both the Pfizer shot as well as the Moderna shot, in both of them the agent pseudouridine was used, as well as the unfortunate use of a number of fats, basically fat envelopes that were used to actually deliver the agent into the body. And these lipid particles, which are actually part of the delivery system, were actually known to be toxic agents when they were created. So this was not something that is an after effect discovery; this was known to be a toxin.
"More importantly, if you actually set aside the lipid nanoparticle for a moment and you go back to the pseudouridine that was part of the injection to stabilize the mRNA so that actually would find its way into the cell and do its work, what you find with the pseudouridine case is that is an active cancer promoter. Now it does it by doing two things. It actually switches on some cancer behavior, but it also shuts down the body's natural response to fight cancer. And all of us, every single one of us, has atypical cell growth happening at some point, somewhere. When that goes out of control we call it cancer, and when we let it go further out of control we call it metastatic cancer.
"And what you're finding, Brian, is what's called 'Stage IV cancer on diagnosis.' Now 'Stage IV' and 'cancer on diagnosis' shouldn't be said in the same sentence, because it turns out that Stage IV talks about the maturity of that cancer. That's an indication of how aggressive, or how long, or how comprehensive that cell line has been established.
"When you find cancer at Stage IV, what it means is there's an accelerant. Something is going on, where something is not only triggering the hypertrophic growth, but the other side of it is the suppressors which are natural in our body, the things that actually bring down cancer as a response, are being themselves suppressed. So what we're left with, is we're left with a pro-cancer trigger, and then we shut down the anti-cancer response that's normal in the body.
[…]
"By 2018, Brian, we knew the pseudouridine thing. That was published science, which means that by including it into the shot, both Pfizer and Moderna willfully killed human beings, and I want to say that unambiguously."
Dr. David E. Martin with Brian Rose @ 18:38–20:57 & 27:36–27:53 (posted 2024-07-03) https://rumble.com/v55af7l-dr-david-e-martin-ww3-global-catastrophe-over-2-billion-will-suffer-gruesom.html?start=1118
Damage to melanin in brain leads to mental disorders. Repair melanin damage with light stability inside the tropics
Dan Lawson: "When somebody says the biophysics for mental health, like what picture should they have in their mind?"
Dr. Jack Kruse: "It's a broad question. Everything about health is tied to those three metrics that you mentioned in the opening, which is light, water and magnetism. […] The neural system uses electricity, but the electricity in us starts first with light. And how to make that electricity that goes through our frontal lobes, and going to places that cause most of those mental illnesses is where […] the cornerstone of foundation of health begins, where good cognition, good consciousness begins.
"You can stave off all the mental illness, and that begins with melanin, which is a pigment that […] absorbs all frequencies of light. From that pathway that it absorbs the light when it gets hydrated by mitochondria, because our mitochondria make water, it decreases its electric capabilities. And where mental health is eliminated in terms of bad disease, is that current has to be about one trillionth of one ampere throughout the neurologic system.
"And this is say, go the other way, say places where it's absent or that one trillionth of ampere is gone, then you get low dopamine, you get things like food disorders and depression. You go the other way and say the melanin gets dehydrated because your mitochondrial functions stinks, then you wind up with a disease called schizophrenia, which is chaotic […] Why? because it's extremely high and it's not released in a circadian fashion. In other words, when the neural structures need it, you're not able to maintain that tension in that neural tract and you wind up with another disease. […]
"The light spectrum is really the key in understanding how this thing is put together and how melanin is the motherboard for, I guess you'd want to say the hardware, which is our brain. Then you begin to understand a new way that cognition is built and then mental wellness is built."
[…]
"The basis of cognition, consciousness and mental disorders is that DC current. And that DC current, turns out it has to be really honed with precision. It's quantum mechanical. What does that mean? That any degree that it's off means that you're signaling in your brains off. In other words, if you really want to get rid of that bipolar disorder, it's going to be really difficult to do in an environment that doesn't give you any light stability.
[…]
"Say you do have one of these disorders that you're interested in, I would submit to you that it makes far more sense for you to probably relocate for one, two, three or four years [to inside the tropics], leave the Zoloft at home, and see how nature treats you. Because if you start to notice that when you get light stability and you're able to rewire your brain, you're able to put alpha MSH, melanin, POMC working in your brain and those neural tracts come online, your friends and family may say, 'Hey, you're a different person when you go down there, and we're starting to notice this as a difference.'
[…]
"I can tell you, those with the severest mental illness, what I tell them when I see them, you're looking at three to five years inside the tropics. Why? That's how long it takes to rebuild the aromatic amino acids that make up all the neurotransmitters.
"But the number one defect that these people have is they have a melanin defect inside their brains. And the melanin is critical to developing the DC electric current. […] If you can't pull that electric charge, you don't have melanin. It tells you it's a photobioelectric story. It's not a pharmaceutical story."
Dr. Jack Kruse with Dan Lawson @ 04:38–08:06, 24:37–25:02, 29:07–29:41 & 36:10–37:10 (posted 2025-09-10) 

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Exposing the Lie of Hormonal Imbalance: Dr. Jack Kruse and the Biophysics of Optimal Mental Health - Smuggling Hope - Podcast on iVoox
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Your "chemical imbalance" is really a light imbalance. Light needed to make dopamine, norepinephrine, GABA. A lack of UV light in Buffalo
Dan Lawson: "A lot of times people will say, you know, you're 'chemically imbalanced.' They're 'chemically imbalanced,' and that's why they need Prozac. They're 'chemically imbalanced,' and that's why they need Abilify. . ."
Dr. Jack Kruse: "Well, guess what? All those drugs are not in you. They have no evolutionary basis in humans. Just remember that. These are chemicals that Rockefeller Medicine makes to give you that's somehow supposed to replace what you were designed to make naturally? This is crazy talk. […]
"The way this works is certain frequencies of light tie to those aromatic amino acids that make the chemicals […] like dopamine, norepinephrine, GABA. […] These chemicals all have an absorption and emission spectra for light. […] What happens if you don't get that light? Well, then you don't make that chemical. There's your 'chemical imbalance.' Turns out your 'chemical imbalance' really is a light imbalance.
"The light in Buffalo, it's not equivalent to the light in El Salvador. It's very simple. And it never did. That's the reason why you've had this disease your life long. […]
"Amino acids have a specific spectrum. […] The amino acids that make up all these neurotransmitters have the same effect. […] When you start to tell people that dopamine […] has a strict UV absorption pattern, well, do a hard stop.
"Tell me, my friend in Buffalo, when do you get UV light? Maybe three months out of the year. That's it. So you understand why it's more common there than it is where I live down in El Salvador, well, there's your answer. I mean, it's pretty simple.
"And the thing is, then people will say, 'Hey, Jack, can I go to the PetSmart and buy a snake light or a reptile light and use that from that go?' Well, again, that's another solution that is B, C or D. Now, ironically, I'm going to tell you something I probably shouldn't. If you use a purple and red light in your house, is that better than Abilify and Zoloft? Probably. When you hear that kind of remark, you start to go, 'Well, I only need to buy one red light, one reptile light. I'm going to give this a shot.' […] You could try them. And I'd be okay with you trying that at home before you try, you know, using the drugs.
"And if you start to notice, this is crazy, I'm actually getting better. Then, then the next step is, OK, now I need to do everything I can to get to a better environment because you know what, I'm not interested in being sick, I really like to reverse this problem functionally. For many people who are, let's just say, their-toe-is-in-the-pool sick, you can do small amounts of things to move the needle a big way. The people that are really sick, the people that are close to institutionalization, no, they're going to need something way more than that. Why? Because the hole that they're coming from is a much bigger hole."
Dr. Jack Kruse with Dan Lawson @ 40:53–44:24 (posted 2025-09-10) 

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Exposing the Lie of Hormonal Imbalance: Dr. Jack Kruse and the Biophysics of Optimal Mental Health - Smuggling Hope - Podcast on iVoox
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Change breathing pattern to stimulate the vagus nerve, reduce inflammation. Slow, gentle breath out to stimulate the vagus nerve. The key is the exhalation
Patrick McKeown: "It's known since 1998 that if you stimulate the vagus nerve you can block pro-inflammatory cytokines.
"So there's a neuroscientist from New York called Kevin Tracey, and he was working on rats doing experiments. His hypothesis was if I can stimulate the vagus nerve in the rat I can reduce inflammation. His colleagues were outside in the corridors betting, making bets that it wasn't going to happen. And he showed it could. [...]
"Stress contributes to inflammation, and inflammation is making us sick.
"So then we have to ask is in terms of the vagus nerve, how can we stimulate the vagus nerve? And the vagus nerve can be stimulated by changing our breathing patterns. [...]
"The vagus nerve is a nerve that wanders throughout the human body. it innervates all of the major organs, for instance, the diaphragm. [...] 80% to 90% of the information by the vagus nerve is from the body up to the brain. [...]
"But it's known since the early 1900s that if you stimulated the vagus nerve, you caused the heart rate to slow down, because by stimulating the vagus nerve it secretes a neurotransmitter called acetylcholine.
"So that's why, you know, when we were talking about, say, high performance, if you go into a situation and you feel that your heart rate is elevated, if I go out on stage and if I feel my heart rate is too fast and too strong, I want to bring this down. What do I do? I just take a soft breath in through my nose, and the really relax and slow, gentle breath out. I don't time the exhalation.
"The key is the exhalation, not the inhalation. I don't time it because I want to soften and slow down my breathing relative to how I'm breathing at that point. We all breathe differently [...] depending on the situation. If I slow down the speed of the exhalation, it stimulates the vagus nerve, that secretes acetylcholine. That in turn is causing the heart rate to slow down. But also by stimulating the vagus nerve it's helping to block pro-inflammatory cytokines, which are the chemical messengers that trigger inflammation. So changing our breathing pattern we can reduce the risk of inflammation."
Patrick McKeown with Mads Tömörkènyi & Jakob @ 01:34:05–01:36:56 (posted 2024-07-21)
Learn breathing techniques to get out of your head and enter flow. Enter flow to reduce anxiety, stress, and depression
Patrick McKeown: "So we talk about people with anxiety and panic disorder and even racing mind and lost in thought. An athlete or somebody comes into my door. OK, they're coming in my door because they're looking for breathing for physical performance. I will spend at least half the time getting them out of their heads. And the reason being is because the courage in this instance is to be able to reproduce flow states, that you're fully immersed in what you're doing, because this is a state of bliss. It's a tremendous stage where the right action is happening by yourself, by itself; your attention is moving simultaneously with time.
"But in order to achieve that stage your brain is trained, or at least you have some degree of control over your thinking, or whether you're lost in thought or not. Now once you developed that, you also have developed the capacity to step outside of thought. That's very important, because I have developed the capacity not to be anxious, not to be lost in my mind, not to be having. . . I don't think that I have a risk of depression, because I can step in when I notice that my mind has gone a little bit too far, if I'm ruminating. And I feel then that I'm not going to run the risk of ruminating myself into the ground.
"So on one hand, we're talking about flow and we're talking about mental performance. But of course, the things that we learn to achieve flow, those same traits will also help keep us out of trouble, reduce our anxiety, reduce our high stress, reduce our depression."
Patrick McKeown with Mads Tömörkènyi & Jakob @ 01:32:03–01:33:46 (posted 2024-07-21)
Lost in thought? Improve breathing to improve concentration
Patrick McKeown: "So with _Oxygen Advantage_, I would say that 50% of our training is breathing, and 50% is getting people out of their heads and into the body, and developing the capacity to be able to hold attention. Now, when we think about concentration, what is it? Concentration is your ability to hold your attention on one thing in the absence of distraction, that you're not looking through. . . your energy isn't directed through this veil of thinking. [...] It's not that you're just looking at it.
"OK, give you this example. You could be reading a book, as I would have been for years, and my eyes are looking towards the text. So to an outside observer they think I am reading the book. My eyes are looking at the text but it doesn't mean my attention is on that. My attention could be stuck in my head, and I could be reading that, and I'm lost in thought. I get to the bottom of the page, I remember nothing of it. That's not concentration."
Mads: "That's me. [laughs]"
Patrick McKeown: "Concentration is your ability to hold your attention there exclusively, that 100% of your attention, that you're fully immersed in what you're are doing.
"Now if somebody can develop that skill they have it for life. Their quality of work, regardless of whatever they apply themselves for it, will be a good quality of work, because you can't produce good quality of anything if you're just going through the motions."
Patrick McKeown with Mads Tömörkènyi & Jakob @ 01:28:45–01:30:11 (posted 2024-07-21)
Breathing to bring a quietness & stillness to the mind. Seeing Grafton Street for the first time
Patrick McKeown: "How do you conduct yourself in your normal, day-to-day activities? We have a choice as human beings: we are either stuck in our head or we are not. And I'm not talking about being in our mind and thinking about practical purposes. There is a time to think, to make decisions, to plan, to question. There's a time to think, and that's very practical, and that's very important for human beings, because we do have to think things through.
"But there's a time to stop thinking. The problem is that we have develop the thinking mind into such an instrument involved with thinking, we just cannot stop thinking. Our education system has trained us how to think for 12 or 14 years. It has trained us how to think, but it hasn't gave us the tools to be able to bring a quietness and a stillness to the mind. Because if we are living our life stuck in our head, it's not a nice place to be. The human mind is not a nice place to be. […] We all have a tendency to overthink. […]
"If you were to break it down it's actually so simple. Stop thinking. Yeah, so stop thinking. OK, and you say, 'Well that's not so simple.' Well, but actual fact it's not that hard, if you compare the alternative. What the alternative? Living stuck in your head, totally isolated from life. You can't live life. Like, I was that individual.
[…]
"When I came across breathing I was lucky enough to. . . I went to a two-hour talk in Dublin in a hotel and it was obviously gave by people, two individuals, who were in a state that they were immersed in presence. And there's one thing about human beings that when we talk about bringing a stillness and a quietness to the mind, it's not necessarily the words that we are transmitting. But there's something else that goes beyond the words and I don't want to sound too woo woo here because it's difficult to kind of objectively break it down scientifically.
"I left that two-hour talk and I walked down Grafton Street, which is a street in Dublin, it was the first time that I actually saw the street. Now I had walked that street numerous times and I can still remember. I can remember the colors, I can remember the sounds, I can remember the feeling, and I can remember the silence of my head. And it wasn't, you know, it was just different. I didn't really know what was going on but I got a taste. […] It was almost as if the critical mind had just been put aside for that brief period of time because whatever I'd listened to these two individuals.
"It wasn't that I was in a state of hypnosis or anything like that going down the street. But it planted a seed in me that even though I woke up the next morning I was still back to that racing mind, because of the societal pressures for young kids. […] I was in my early 20s at the time. You know, that drive to succeed, and the pressures that we put upon ourselves."
Patrick McKeown with Mads Tömörkènyi & Jakob @ 22:25–24:36 & 26:15–27:53 (posted 2024-07-21)