because of the mind body link, placebos are often more powerful than most drugs. i love this analysis of placebo for treating depression:

PubMed

Association of Single-blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants: A Systematic Review and Meta-analysis - PubMed

This study suggests that RCTs using PRI periods yield smaller within-group changes across both placebo and drug groups compared with RCTs without P...

placebos are 40% effective and drugs 54% effective, which means that 74% of the drug's effect is explained by the placebo effect.

"In 2016, journalist Del Bigtree issued a challenge to the head of infectious disease at one of the most prestigious medical institutions in the world: conduct the most thorough vaxxed vs. unvaxxed study that has ever been done. The expert took up the challenge and ran the study to prove Del wrong. That study never saw the light of day... until now."

An Inconvenient Study

WATCH NOW | An Inconvenient Study

An Inconvenient Study: This could change everything. An ICAN Production.

methylene blue is only useful if you have mitochondrial dysfunction. unfortunately there is no way to know if you have issues with your electron transport chain on the mitochondrial level. Most likely, people with many types of cancer and those with advanced dementia do have problems at the mitochondrial level but it is unfortunately trial and error to see if methylene blue produces any clinical effects. People with viral like illnesses also may have issues and experience benefits at low doses (<16mg/day). The problem arises when people use methylene blue like a stimulant because it does produce anti-depressent like effects (as a monoamine oxidase inhibitor). If you want an antioxidant, metheylene blue is not a good choice as it only works in one special place (complex III). You are better off drinking H2 water and getting direct reduction rather than anti-oxidation.

hopefully tariffs make soybeans and soy protein additives and soy oil very expensive. humans should not be consuming soy https://www.ajol.info/index.php/ajfand/article/download/55335/43797

antibiotics are prescribed way too indiscriminately especially for kids without any thoughts to the short and long term impact to gut microbiology. most people will need pre and pro biotics post antibiotic use and very rarely receive recommendations for high quality regimens. for example, ear infections (otitis media) is significantly influenced my microRNA (miRNA) produced by gut flora.

Frontiers | Exploring the role of gut probiotic metabolites in the prevention and treatment of otitis media

it is increasingly likely that the miRNA produced in our gut influences our gene expression and our ability to resist a disease state. We are more a product of our gut than modern medicine understands.

In the US, a new non profit hospital requires a Community Health Needs Assessment (CHNA) which basically assesses if an unmet need for a new hospital exists in the community. A new hospital (unless it is for profit ) can't just build and try and outcompete existing institutions. Even more perverse is the fact that existing hospitals get to weigh in via statements and data about why existing needs are being met. Indirectly hospitals are essentially asked to get permission from other hospitals before starting.

although still more expensive compared to other snacks, it is increasingly common for kids to be educating friends' parents on seed oil free snacks "Mom, we should buy Siete chips" "Dad, the lesser evil popcorn is great" "Froot thief is better than fruit by the foot"

prong horned antelope aka "speed goat"

the issue with nicotine pouches isn't the nicotine (in very high doses it's dangerous but otherwise is fairly similar to caffeine use) the issue is the: 1. Sweeteners: acesulfame K, sucralose, aspartame, xylitol --> disrupt gut biome, cause hunger signal dysfunction 2. Stabilizers: sodium alginate, propylene glycol (PG), vegetable glycerin (VG)- hepatic stress and testosterone disruption and GI distress

your pineal gland is not supposed to be calcified. however, 75% of people over that age of 25 have a significantly calcified pineal gland. the most likely cause is excessive consumption of fluoride via fluorinated water and fluoride in your toothpaste https://www.mdpi.com/2076-3417/10/8/2885

i've been experimenting with posts to see what people like. seems like deep dives on medical topics get the most feedback. i'll post a lot of nutrition stuff but unpacking research is most satisfying to me.

most vitamin D3 (cholecalciferol) capsules are semisynthetic it is extracted from lanolin (sheep's wool). The lanolin contains 7-dehydrocholesterol, which is then exposed to UV light to convert it into Vitamin D3 (cholecalciferol) Some "vegan" Vitamin D2 (ergocalciferol) supplements are produced by exposing lichens to ultraviolet light. humans can store vitamin d in adipose tissue (fat soluble) for indefinite periods of time. The more time you get in the sun during the summertime the less likely you are to need any vitamin d in the winter regardless of where you live on the planet.

it is my prediction that we will find that metabolic dysfunction is at the heart of mild and severe dementia we can basically think of dementia as "diabetes of the brain". https://www.sciencedirect.com/science/article/pii/S1568163725000595

The thyroid produces mostly thyroxine (T4), which must convert to triiodothyronine (T3) — the active hormone. Polyunsaturated fatty (PUFAs) acids slow this conversion, possibly by: 1. Inhibiting 5’-deiodinase, the enzyme that converts T4 → T3 2. PUFAS also increasing oxidative stress in liver cells, which impairs normal metabolism 3. PUFAs and their oxidation products can bind to thyroid transport proteins or cell receptors, reducing how effectively T3 gets into cells. 4. Animal studies have shown that feeding high-PUFA diets can lower TSH output from the pituitary gland, slightly reducing thyroid stimulation.

super interesting epidemics study in mice: "Paternal exercise confers endurance capacity to offspring through sperm microRNAs" https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00388-2 male mice after being trained for endurance exercises showed expression of microRNAs in their sperm that increased mitochondrial synthesis in the next generation.

the soon and longer you read outloud to your children the better they will be in all aspects of life https://www.researchgate.net/profile/Juan-Mata/post/Can_you_help_me_finding_recent_studies_about_parental_involvement_in_reading/attachment/59d645bc79197b80779a0ceb/AS%3A454465254891521%401485364368305/download/ReadingAloudtoChildren_ADC_July2008.pdf i think the most under appreciated aspect is the ability to sit still and concentrate using their imagination at the same time.

if you can visit yellowstone in october, it is wonderful. not crowded with tons of wildlife

healthcare administrators are a product of the government management of healthcare. the amount of burden from accreditation agencies alone take half of these administrators and insurance makes up the rest @TFTC

in medicine, it's much more acceptable to do what is recommended than to do what is true 

abs are made in the kitchen. discipline is made in the gym