I have not found a reason to use Simplex if you are doing WebRTC. Instead of Nostr -> SimpleX -> WebRTC, you might as well just do Nostr -> WebRTC. It's one less point of attack.

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The point of simplex is the async queues which you can’t replace with p2p tech. Nostr is missing the ephemeral push-pull queue idea
Async queues could fit nicely into relays. The queues are a really interesting solution in my opinion and I wonder where is that applicable in Bitcoin or Nostr space...