Would it be possible to build a limiter like what twitter has where people you dont follow can't reply or otherwise engage with you? If people who are harassed are given control to consent to social interactions as a starting point, that might be worth considering.

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Yeah, that's basically what I'm proposing. On protocol level it's possible to craft any type of note, but relays could check - if a note contains reference to npub that blocks mentions by you - they wouldn't accept or propagate your note. They also could stop returning your notes if the request is by certain npub.