Tim Ferriss is not a scientist. He’s a self-proclaimed human guinea pig. His study of the human body may not be rigorous, but he and others who self-experiment and introspect still offer valuable insights. Their experiences can help us understand health and wellbeing more completely, and they deserve a seat at the table. Last month Tim posted an insightful article ( about his perspective on the project of physical performance optimization in humans. The basic premise: there are no biological free lunches. Most optimizations of one trait come with a non-negligible trade-off in some other trait. I would go further than Tim: I believe his premise expands beyond just performance optimization to almost every aspect of human health. Look at his first three heuristics: 1. Assume there is no biological free lunch. 2. Assume that the larger the amplitude of positive effect of *anything*, the larger the amplitude of side effects. 3. Don’t ask a barber if you need a haircut. If you agree with these, why shouldn’t they apply to almost every pharmaceutical, or in fact every exogenous compound? Which brings me to the title of this post: Ozempic. Ozempic is proving to have enormous positive effects on the dimension of human weight loss. The barber recommending the haircut, Novo Nordisk, is now Europe’s most valuable public company. I predict that we’ll find out that what looked like a biological free lunch was too good to be true and that Ozempic will follow in the footsteps of other biological free lunches before it. image

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