Wow, is it easy to outline the main differences or not? I am running knots now but it is really hard as a non-coder to know what to do essentially you’re just taking sides where you can’t verify the truth yourself
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For context, Bitcoin Core has something like 240'000 lines of c++ code.
I don't intend to take the time to go through someone of that magnitude, but if you want to take a look, here's the diff: 
GitHub
Comparing bitcoin:28.x...bitcoinknots:28.x-knots · bitcoin/bitcoin
Bitcoin Core integration/staging tree. Contribute to bitcoin/bitcoin development by creating an account on GitHub.