Setting up all the DNS records right takes some effort, yes. You will need a VPS or an ISP that gives you a static IP and the ability to set the PTR record for it.
Other than that, self hosting without losing email is perfectly possible. I have been doing it for the last 10 years or so.
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But IMO it is not worth it over Protonmail (or similar) even if possible. Better to live with the fact that E-Mail is not and will never be private.