For command line there's 
Don't remember if there's another desktop app besides nak
GitHub
GitHub - fiatjaf/nak: a command line tool for doing all things nostr
a command line tool for doing all things nostr. Contribute to fiatjaf/nak development by creating an account on GitHub.
Use a signing app, then only one app will have access to your private key.
Android only. Supports most Android apps & bunker connections.
https://github.com/greenart7c3/amber
Cross platform, supports bunker connections.
https://github.com/ZharlieW/Aegis
https://github.com/haorendashu/nowser
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