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Notes (20)

Alguém do Nepal? Alguma informação??? 👀
2025-09-09 17:21:25 from 1 relay(s) View Thread →
🚨 BREAKING: President Trump just signed an executive order directing the DOJ to pursue ONE YEAR IN PRISON for those who burn American flags in the street 🫡 nostr:note1gc6u0gzf0a2jv8uvkul5gjvq8clxwx2s0ttyxnplhnfz5lufp47qam72w3
2025-08-26 00:03:47 from 1 relay(s) View Thread →
Synthetic Phosphoethanolamine and the Analogy with Castor Oil-Based Biomaterials: A Hypothetical Extension of Chierice’s Research The synthetic phosphoethanolamine developed by Prof. Dr. Gilberto Orivaldo Chierice has been proposed as an innovative approach in oncology. Its mode of action has been described as a molecular marker for neoplastic cells that exhibit predominantly anaerobic metabolism, consistent with the Warburg effect, whereby tumor cells prioritize glycolysis even in the presence of oxygen, leading to excessive glucose consumption and lactate production. Chemically synthesized through an alternative route, synthetic phosphoethanolamine structurally mimics endogenous precursors of phospholipids such as phosphatidylethanolamine and phosphatidylcholine, which are crucial for the integrity of both cellular and mitochondrial membranes. The hypothesized mechanism of action involves signaling the immune system to induce selective apoptosis in malignant cells, mediated through modulation of mitochondrial potential and lipid dissolution of tumor cell membranes, without affecting normal cells. A less widely discussed hypothesis, here referred to as the “secret mechanism,” involves the hepatic biotransformation of synthetic phosphoethanolamine. In this model, the compound conjugates with fatty acids, forming a specialized phospholipid capable of infiltrating the membranes of anaerobic cells. This process would theoretically counteract the Warburg effect by restoring oxidative aerobic metabolism, promoting carbon–carbon bond cleavage into CO₂, and enabling tissue regeneration within a period of 6–8 months. This hypothetical framework can be logically compared with other biomaterials also developed by Chierice, particularly castor oil–derived bone prostheses (polyurethane scaffolds from Ricinus communis). These biomaterials are injected in a viscous state, solidify upon contact with blood, and function as biodegradable scaffolds that are progressively replaced by native bone tissue without eliciting immune rejection. From this perspective, synthetic phosphoethanolamine could be understood as a “molecular scaffold” in oncological applications, potentially guiding the transformation of tumor tissue into normal tissue. Such a mechanism, if confirmed, would represent a low-cost and accessible therapeutic approach, while also challenging conventional pharmaceutical paradigms. It must be emphasized, however, that the notion of a “hepatic phospholipid” capable of reversing the Warburg effect remains speculative and has not been experimentally demonstrated. This conceptual extension arises from an analogy with the castor oil–derived scaffolds, which themselves function effectively in practice despite incomplete mechanistic elucidation. In summary, synthetic phosphoethanolamine—hypothetically modified in the liver through conjugation with fatty acids—might form a novel phospholipid species capable of resetting the Warburg effect. This would, in theory, force tumor cells into oxidative respiration, trigger selective self-destruction, and promote tissue regeneration, in a manner conceptually parallel to the regenerative capacity observed in castor oil–based prosthetic scaffolds. image
2025-08-22 05:52:29 from 1 relay(s) View Thread →
😆 nostr:note1f835hha0ya0w32m35cyrge0fmfzw9sshplf3md8vn772lejjhnsqh8zp9c
2025-08-19 18:11:11 from 1 relay(s) View Thread →
Everyone won... Lula gains an excuse for economic failure and reinforces the proposal of the southern BRICS global currency. Companies and people run to the USDT in search of a Safe Harbor. The more the USDT circulates, the more Tether buys debt, dollar protected against eviction from some other country. The natural path leads the user from USDT to Bitcoin and do you know who wins? USA “biggest holder” and Trump for the bet. Don’t think they’re not thinking about it, while people just get screwed... https://video.nostr.build/4c2d98f9f80961475f9b44123fb5db98cab2c6dedfdacdfddf0bd96b96680bc7.mp4
2025-08-18 18:50:17 from 1 relay(s) View Thread →
🇧🇷 Brazil 👇 nostr:note1l0quullavmxmgtc33upaptlfcwx9mq478zvmrehmla3wy7p995gqc3krcy
2025-08-11 12:46:42 from 1 relay(s) View Thread →
🚨IMPORTANT!!! Mandatory Facial Recognition on Networks? PL 1380/2025, which requires facial recognition to access social networks, is already being processed in the House. With Hugo Motta's recent statement on prioritizing platform regulation projects, there is a growing possibility that this proposal will be put on the agenda. The "for security" discourse is the gateway to a mass digital surveillance system. image
2025-08-11 12:46:13 from 1 relay(s) View Thread →
Today I received my second rent in bitcoin... I feel in the future!
2025-08-05 21:11:51 from 1 relay(s) View Thread →
ATTENTION: President Trump has already been informed that Alexandre de Moraes has ordered Bolsonaro’s arrest. image
2025-08-04 22:22:56 from 1 relay(s) View Thread →
🇧🇷 Police are at Bolsonaro’s home right now, following a house arrest order signed by Alexandre de Moraes — just hours after the release of the “January 8 Documents,” which expose the Supreme Court Justice himself. Congressman Marcel van Hattem denounces: “Of course it’s not a coincidence.” image
2025-08-04 22:06:32 from 1 relay(s) View Thread →
Dissatisfied by nature! Common man enjoys comforts that, in times past, were unknown and inaccessible even to the wealthiest. But, of course, automobiles, televisions, and refrigerators don't make a man happy. The moment a man acquires them, he feels happier than before. But as soon as some of these desires are satisfied, new ones arise. Human nature is like that. image
2025-08-03 19:05:43 from 1 relay(s) View Thread →
Xandão vai viver como um bitcoinheiro maxi: pedindo pro segurança pagar a cervejinha no estádio, pros amigos cobrirem o táxi e pros familiares ajudarem com um boleto. Vai tentar de várias contas, bagunçar tudo e perder muito dinheiro… Com o tempo, vai descobrir que ninguém tem o suficiente pra cobrir suas necessidades — não porque o BTC valorizou, mas porque ele ganha um salário irreal! Mas a sensação vai ser a mesma que a gente sente… só que sem o orgulho! Profetizei… image
2025-07-31 02:13:17 from 1 relay(s) View Thread →
Before going to sleep… Trump shouldn’t trade his gold reserves for Bitcoin. The only thing preventing the rest of the world from creating a widely accepted and auditable stablecoin is the fact that the U.S. benefits from holding most of the global reserves. As soon as that changes, they’ll start trading dollar-backed stablecoins for gold, and the U.S. will lose one of the most consistent buyers of its debt. My guess is: knowing this, instead of selling gold for Bitcoin, he’d launch a gold-backed stablecoin — anticipating the move and profiting on both ends.
2025-07-30 04:22:14 from 1 relay(s) View Thread →
🚨TSUNAMI ALERT🚨 Don't forget your seeds!
2025-07-30 01:23:55 from 1 relay(s) View Thread →
🚨 earthquake 🚨 near Russia from 8 to 8.7. image
2025-07-30 01:18:18 from 1 relay(s) View Thread →
Quem é do Brasil? 🇧🇷 Da um alô que sigo… vamos agitar isso aqui! Sem política…. Esquece eles!
2025-07-26 23:47:22 from 1 relay(s) View Thread →