This is really interesting: https://www.nature.com/articles/s41562-024-02046-9 "Large language models surpass human experts in predicting neuroscience results" A study on how well trained LLMs can predict the "correctness" of a new neuroscience study/claim based on looking into the associations of the mentioned claims/words in the new study compared to a reference set of thousands of previously published neuroscience papers. The idea here is that there are associations hidden in the vast amount of literature out there that humans in general and singular scientists in particular just cannot read, remember, grasp and comprehend anymore due to the exponential growth in studies. Importantly all thus trained LLMs outperform a large panel of human expert in predicting whether or not a new study or a fake study is true. This is really fascinating and could have major implications to identify new disease MoA hypothesis, target validationa nd dicovery, discover hidden connections and low-hanging treatment option fruits that nobody has yet considered or simply just weed out fake or irrelevant new er publications. #ai #science #neuroscience #drugs #future #LLM #nostr

#bitcoin #nostr #memes

My favorite euphemism from corporate world is "let's take a bio break"

Today, I experienced a first: someone told me they got interested in Bitcoin after reading my book and now plan to buy some. Made my day to know I finally managed to orange pill someone! #bitcoin #books

Another ALS clinical trial failure:

Fierce Biotech

PTC axes utreloxastat program after phase 2 ALS failure

PTC Therapeutics’ amyotrophic lateral sclerosis (ALS) prospect has

Unfortunate but sad reality when it comes to CNS disorders. The problem mostly stems from our fundamental ignorance (in the classical meaning) when it comes to these disorders. We truly mostly still don't understand what is the underlying key mechanism of action that needs correction in order to treat these diseases. #science #als #brain #motorneurons

Are LLMs better doctors? LLM model on its own far outperforms physicians when giving the correct diagnosis. Funny thing is, even when physicians are allowed to use AI as support, their correct diagnosis ratio basically does not increase, indicating a tendency of the physicians to cling to their own diagnosis and ignoring the LLMs advice. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2825395 #ai #science #health

playing around with AI-generating video for scenes from my book. I wanted an intense fight in hotel room between a middle-aged US agent and two Chinese bodyguards. I received a beautiful choreographed modern dance triplet of a Chinese Christopher Walken and two supporting dancers. Long way to go. #ai #art #artstr #books #funny

ok,this is just beautiful #sun #universe #science

There is „Broken Money“, there is "The Bitcoin Standard“ but the most interesting I've so far read about the monetary system is „The Creature from Jekyll Island: A Second Look at the Federal Reserve“ by G. Edward Griffin. I can only encourage every bitcoiner to read it. It is excellently written, very engaging & goes in many ways to the core of what the problem with current fiscal policies and banking system is about. For example, right from the 1st chapter: "The purpose ... was to come to an agreement on the structure and operation of a banking cartel. The goal, as is true with all cartels, was to maximize profits by minimizing competition between members, to make it difficult for new competitors to enter the field, and to utilize the police power of government to enforce the cartel agreement. In more specific terms, it was to create a blueprint for the Federal Reserve System. Here were representatives of the world's leading banking consortia... driven together by one overriding desire to fight their common enemy. The enemy was competition. Competition also was coming from a new trend in industry to finance future growth out of profits rather than from borrowed capital…between 1900 and 1910, seventy per cent of the funding for American corporate growth was generated internally, making industry increasingly independent of the banks.... What the bankers wanted … was to intervene in the free market and tip the balance of interest rates downward, to favor debt over thrift. To accomplish this, the money supply simply had to be disconnected from gold and made more plentiful … ." This is just from the 1st chapter and it continues to be enlightning and revealing. In my view it shows even better than Lyn's or Saif's books how the creation of the debt-based money supply system, the creation of the FED and the move away from the gold-standard was not a natural development that simply had to occur for a modern society to function but was instead driven by the influence of a few conspiratory bankers. #nostr #bitcoin #books #bookstr #money

Goodreads

The Creature from Jekyll Island: A Second Look at the F…

Where does money come from? Where does it go? Who makes…

quite interesting and promising results for a potential new therapy for diabetes 2 patients. "Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%."

Novel procedure combined with semaglutide may eliminate insulin dependency in type 2 diabetes

Novel procedure combined with semaglutide may eliminate insulin dependency in type 2 diabetes

#science #diabetes

Am I officially old if the only acceptable breakfast #music is a Playlist with oldies like Aretha Franklin's "I say a little prayer" or "Happy Together" from The Turtles? Music on modern breakfast playlist grinds my nerves and the typical breakfast/morning coffee shop music makes me want to go back to bed. #asknostr #oldies #morning #breakfast

Eliezer Masliah, a top scientist in neurodegeneration and top NIH official has likely manipulated hundreds of Parkinson's and Alzheimer's paper and findings over the last 2 decades, potentially leading to billions of misallocated funds and research focus in the broader scientific community. He might get shunned for this in the community but will ultimately fall softly and continue to work in the field. It's a pity that there are no larger repercussions for falsifying data in research given the large implications this can have. https://www.science.org/content/article/research-misconduct-finding-neuroscientist-eliezer-masliah-papers-under-suspicion #science #alzheimer #brain #neurology #NIH #neuobiology #Parkinson #fraud

If anybody is looking for an interesting read, give "The Power of Habit: Why We Do What We Do in Life and Business a try"

Goodreads

The Power of Habit: Why We Do What We Do in Life and Bu…

In "The Power of Habit", award-winning "New York Times"…

I was expecting yet another boring "marketing book" when I picked it up but it goes surprisingly deep into #cognition, #psychology and #society in general. I enjoyed it. #books #science #brain #neurobiology #psychology #reading

Great article from "The Pessimists Archive" about the hot legal debate about "Fake News" and fake photography >100 years in the US. This is just as much applicable to today's AI discussions and the just starting controversy on AI generated deep fakes and the likes. Nothing is really new, history repeats itself & hopefully we as a society can learn and improve from it in the long run. On a side-note: the pessimists archive is a great website in general if you want to read about the worries and fights of the past against new technologies. Pretty much every new technology (electricity, phone, bicycle, cars, planes, etc.) had been vilified, people have been afraid of it and did not understand it before it became common reality. #bitcoin and #nostr are just another link in this long chain of this techno-pessimism.

The 1912 War on Fake Photos

Concern about deceptively edited photos feels like a very modern anxiety, yet a century ago similar worries were being litigated...

"Concern about deceptively edited photos feels like a very modern anxiety, yet a century ago similar worries were being litigated... Portrait photography gave rise to an industry of photo ‘retouching’ - analog ‘beauty filters’ - to flatter subjects in a way portrait painters once did. This trend lead to questions about technology distorting our perceptions of beauty, reality and truth" #nostr #fakenews #photography #deepfakes #ai #bitcoin #regulations #freespeech #

I was listening to @Peter McCormack 's recent podcast with Matthew Pines and their discussion about consciousness as an underlying component of the universe. Interesting on many levels. The philosophy he described from Philipp Goff about the meaning of life that Matthew mostly seems to follow (with some modifications), reminded me a lot about the philosophy described in Gregory Roberts 2003 novel Shantaram that he expresses in the person of Khader Khan which can be summarized maybe as "everything that contributes to the complexity and richness of existence is meaningful" and that the "the universe is driven by the need to evolve, grow, and expand its possibilities" In his words, the whole point of everything in the universe is that the universe becomes more interesting. If one leads a life that maximizes the probability to make the universe more complex, one has lead a good life. Every act of goodness or evil, every choice we make, adds to the complexity and interest of the universe which is how he justifies his role as a mafia leader, as he sees even crime and violence as part of the greater purpose of making the universe more complex. I have not read Goff's book "Why" yet but I wonder if there is some overlap and references to these viewpoints. Would be interesting as Robert's book predates this by 2 decades and comes from a spiritual/religious viewpoint whereas Matthew Pines seems to come more from a rationalistic approach. #books #philosophy #consciousness #universe #purpose #podcast #religion #spirituality

What happened a couple days ago on September 14th that Nostr saw such a spike in new users? Was there an announcement of someone famous that they switch to Nostr? #asknostr #nostr #stats

El Salvador achieves fiscal independence:

El Salvador in English

El Salvador Achieves Fiscal Independence: President Bukele Announces Self-Financed Budget.

President Nayib Bukele announced El Salvador’s achievement of fiscal independence, eliminating the need for external debt and ensuring a fina...