Dr Sam Soete's avatar
Dr Sam Soete
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Decentralised Health Optimisation
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samsoete 2 months ago
Too many people go through life without a single thing that excites them throughout the day. Create a mindset that gets excuted about things. Figure out what excites you. Live a life with more of that in it.
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samsoete 2 months ago
You can tell a lot about a persons childhood (indoor vs outdoor) based on their eye health
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samsoete 2 months ago
From client today 🙏: "A child is a great teacher to be present in the real world"
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samsoete 2 months ago
Micronutrients don’t directly signal satiety, but they enable mitochondrial energy flux and efficient fuel utilzation. What does that mean for hormonal health (which are signalling molecules at the end of the day)? Thyroid hormone signals energy availability. It is basicslly telling the body: "Operate as if fuel and oxygen availability are sufficient to sustain a higher rate of energy flux" BECAUSE THEY ARE. Because ypu are micronutrient maxxing (and mitotoxin minimizzing)
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samsoete 2 months ago
If SSRIs helped your mental health, optimising methylation status may give you relief without side-effects of pharmacteucials. DNA methylation silences expression of neurotransmitter transport genes resulting in increased levels of serotonin & dopamine activity. This is oversimplified, many mental health issues can stem from overmethylation as well but it is worth looking into.
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samsoete 2 months ago
Micronutrient maxxing is actually a lot of fun. Just know that if your digestion is compromised covering intake requirements isnt enough. Its worth looking at functional markers to check if pathways utilizing specific vitamins and minerals are working optimally. Those with chronic issues likely need significantly more than RDAs. But for health optimisation purposes, it is a great skill to cover these nutritional bases with food rather than supplements.
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samsoete 2 months ago
This will rub a lot of people the wrong way but long-term tolerance to a wide range of fibres is often a marker of a healthy gut. Many will settle on elimination diets as it feels great, rather than taking the (sometimes intricate) steps of rehabilitating the gut terrain to allow reintroduction of once not tolerated foods.
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samsoete 2 months ago
Sleepy Milk Tea - For Optimal Sleep & Recovery This is my sleep milk tea recipe that I drink every now and then. It is sweet and tastes incredible (in my opinion). I dont drink it every evening, just when I feel a bit too wired. The base involves creating a very concentrated chamomile tea and mixing a small volume with gently heated milk and a teaspoon of honey. Then I add: - 5g of colostrum - 3g Taurine - 2g Glycine - 4g Myo-inositol. You can drink this with 200-600mg L-theanine and 300mg magnesium glycinate. This combination supports parasympathetic tone and GABAergic signalling. image
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samsoete 2 months ago
There’s a reframe I think is crucial for anyone dealing with long-term issues. Many people remain, to varying degrees, in a state of anxious grasping for "how things used to be." Before forward momentum can be built, there’s usually a period of full acceptance required. Accepting where you are, how you are, right now. Almost like finally hitting solid ground after a long fall and finding your footing. This mental base is crucial. Building a foundation fo where you are, even if it’s not where you once were or hoped to be. Kind of like a sense of being grounded - "I’m no longer falling".
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samsoete 2 months ago
Don't underestimate how important optimal vitamin D levels are for healing the gut. It regulates the integrity of the gut barrier/permeability/leaky gut. Increases tight junctions. Vitamin D plays a role in the innate immune system. It upregulates intestinal alkaline phosphatases which helps to detox endotoxins like LPS. Also got antimicrobial peptides like cathelicidin. Vitmain D also regulates paneth cell function! It alters microbiome composition = more diverse, anti-inflammatory. Reduces general gut inflammation and also makes the immune system more tolerogenic, less Th1/Th17‑dominant responses.
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samsoete 2 months ago
Side-questing 2026 - Levelup Free-diving - Levelup Spearfishing - Levelup Paragliding - Intro Steel Mace - Intro Kite-surfing - Intro Overlanding
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samsoete 2 months ago
UVB exposure potentially increases abundance of SCFA-producing bacteria.
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samsoete 2 months ago
But sure, keep listening to your pale demon dermatologist... image
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samsoete 2 months ago
In SIBO, treatment often becomes overly focused on pathogens, while insufficient attention is given to the impaired gut terrain and motility factors that permitted bacterial overgrowth in the small intestine.
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samsoete 2 months ago
If you have gut hyperpermeability (leaky gut), ulcers, motility issues, don't underestimate the importance of not snacking. Just stop snacking entirely. It is not a meme.
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samsoete 2 months ago
GINGER GINGER GINGER = Stomach Health Ginger will forever be underrated for its benefits in gastric and upper gastrointestinal function. It supports the gastric mucosa by enhancing mucus barrier integrity and antioxidant protection. This is literal viking shield wall mode for le stomach vs acidity and bs irritants. Ginger also modulates enteric nervous system activity and promotes coordinated gastric motility = improving delayed gastric emptying (a big driver in refluxers). Then the sexy ginger bioactives (gingerols and shogaols) influence detoxification pathways in the liver. Esp phase II enzymes. Eat more ginger. Grate it fresh on your food. Make ginger teas. Eat pickled ginger. It is fine to have some ginger with every meal. Supplementing ginger extract can be great to help with motility & constipation as well. image
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samsoete 2 months ago
How I respect my food & improve digestion This is a practice I have integrated over the past year, I don't do it with every meal because sometimes I forget, but I love it. Before starting my meal, I close my eyes and visualize the meal in front of me. I think about all the different ingredients that it contains, where they came from, their life story. This helps me to be present and mindful when eating. It gives me a moment to show gratitude to the food in front of me and respect the life it came from and the work that went into putting it in-front of me. Respect & Gratitude = no longer gorging it down in 3 minutes. image
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samsoete 2 months ago
It is interesting that Larazotide led to faster resolution of GI symptoms and more rapid clearance of circulating SARS‑CoV‑2 spike antigen after COVID infection.