The answer is yes.

There is an underappreciated link between fatty liver/NAFLD and gut inflammation/dysbiosis/hyperpermeability. When the intestinal barrier breaks down, bacterial endotoxins enter the portal vein. It drains directly into the liver, so hepatocytes are first exposed to things like LPS. LPS triggers inflammation, ROS, and TNF-alpha release which impairs mitochondrial function. Then there is also the bidirectional link between bileflow and dysbiosis. Ethanol or acetaldehyde produced by certain microbes will overwhelm liver detox pathways. Many people also have a high ammonia burden due to high urease activity in certain bacterial strains -> more pressure on the liver. To the extent that dysbiosis impairs SCFA production, you get further metabolic dysfunction.

Gm

Excessive caffeine use will also deplete B1 status. It reduces B1 absorption & increases B1 wasting at the kidney level. Combine excessive coffee use at work with alcohol consumption after work for long periods of time and you can get into trouble. Not to mention the synergistic requirements of B1 and magnesium.

Magnesium is fundamental to effective vitamin D synthesis and activation. If you can't get your vitamin D status up, look into magnesium repletion.

Gm NOSTR

You don’t get a sunburn through glass because UVB is blocked, but you still get UVA & HEV-driven oxidative damage and collagen breakdown, without the NIR spectrum that normally signals repair and resilience. The protective warning of UVB-induced erythema is gone.

Did you know that farm animals living outdoors don't fatten as easily as those living indoors. 🤔

A study done in 1939 showing the effects of UV light on testosterone. "Exposure of the genital region is more effective than the chest."

Beach reading

Certain local impairments of enzyme function due to localised heavy metal burden for example can create functional nutrient deficiencies in those organs.

Are you bench maxxing anon?

If you are dealing with ANY autoimmune condition, you need to expose yourself to more natural sunlight, especially UV light.

Blessed day.

Something I am grateful to my medical training for is spending an extensive amount of time studying physiology, metabolism & anatomy. These foundations have been crucial to build on through my own self-guided learning & exploration.

Gm Never miss a sunrise

Centralized Medicine = Searching for diagnostic label to initiate generalized pharmaceutical treatment pathway. Top-down, disease-centred framework. Decentralized Health Optimisation = Detecting & Correcting individual imbalances. Bottom-up, systems biology-based framework.

Decentralized medicine empowers everybody to take ownership for their own health. Nobody is coming to save you. You need to make changes to your own life. Its a beautiful gift, but an even greater responsibility.

Mitochondria lie at the heart of chronic, neolithic disease. Don't ever forget it. Take care of your colony.

Decentralized Health & Decentralized Wealth This Is The Way