ketosis is a survival mechanism, it is not a physiologically normal way to live for weeks on end.

The only problem with peer review is the fact almost all studies keep their raw data private --the peer reviewers rarely see the data and when the study is published, the data remains private. there's no need for peer review if every study just publishes raw data -- then anyone can evaluate whenever they want

mortality trends for classic vaccines

Terry Godier

The Last Quiet Thing

Your possessions came alive. Now they won't stop talking.

tools should be predictable and only draw our attention when they are needed.

definitely a classic influencer post but for some people worth a try. removing the social media apps is probabaly the biggest win for most people. no social media, no need for a phone.

creatine use for nicotine cessation: Only have anecdotal evidence to support this in a handful of people who were all hooked on zyn pouches Smokers had lower concentrations creatine in the medial prefrontal cortex compared to nonsmokers

PubMed

Daily and intermittent smoking are associated with low prefrontal volume and low concentrations of prefrontal glutamate, creatine, myo-inositol, and N-acetylaspartate - PubMed

Cigarette smoking is still the largest contributor to disease and death worldwide. Successful cessation is hindered by decreases in prefrontal glut...

https://www.nature.com/articles/s41380-023-02247-0 creatine supplementation increases brain levels

“Heads Up” for Creatine Supplementation and its Potential Applications for Brain Health and Function | Sports Medicine | Springer Nature Link

There is emerging interest regarding the potential beneficial effects of creatine supplementation on indices of brain health and function. Creatine...

nicotine lowers brain creatine → low brain creatine may impair prefrontal function and self-regulation → creatine supplementation might restore those levels and support cognitive function during withdrawal

two good review articles on the harms of food dyes 1.

PubMed

Toxicology of food dyes - PubMed

This review finds that all of the nine currently US-approved dyes raise health concerns of varying degrees. Red 3 causes cancer in animals, and the...

2. https://www.sciencedirect.com/science/article/abs/pii/S0924224425002213 Children are considered especially vulnerable due to their lower body weight (they get a greater weight based dose in a day) Production of Red 40, Yellow 5, and Yellow 6 leaves behind contamination with benzidine and other carcinogens. Dyes have been associated with a colitis, renal insufficiency, hepatotoxicity, pathological changes in the gut, and oxidative stress.

the joy you get from seeing your children try something new and want to keep at it to get better supersedes all possible happiness your might get from work or material accolades

Reason.com

The tax loophole that made U.S. health care unaffordable

The core structural problem of the health care market is simple: The person receiving care is almost never the person actually paying for it.

the exclusion of employer-sponsored health insurance from taxable income has had unintended consequences (as most gov programs do)

absence of evidence ≠ evidence of absence

just started reading this. very good so far

research institutions and professional schools are forced to use high priced research software with terrible UIs because the market is a niche without any competition now with the cost of software approaching zero the people can make useful tools that respect privacy and costs. introducing papertrace.org

PaperTrace.org

PaperTrace.org - We Organize Your Department

Track and organize your department

PubMed

Effectiveness of Commercial and Homemade Washing Agents in Removing Pesticide Residues on and in Apples - PubMed

Removal of pesticide residues from fresh produce is important to reduce pesticide exposure to humans. This study investigated the effectiveness of ...

imho consuming exogenous ketones is a bad idea https://www.mdpi.com/2072-6643/18/4/675

co sleeping is not associated with sids

i'm pretty sure self sovereignty is going to win with these LLM coding tools. i run one of the large healthcare wikis for emergency medicine (wikem.org) and many AI providers just scrape our data and providers are starting to ask chat boxes what to do on shift rather than reading a wiki page. there is no use fighting them to take down queries with our data especially since it is creative commons. so instead, by using their LLMs i built an LLM powered search for emergency docs

WikEM.ai

walking after a meal helps with glucose spikes as your muscles contract and use the glucose that is spiking post consumption

During sleep—particularly slow-wave (deep) sleep—your body upregulates mitochondrial biogenesis, creating new, healthy mitochondria to replace aging ones.

PubMed

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics - PubMed

Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly cloc...

many nutritionists cite the Shanghai Women's Health Study when defending soy as part of a healthy vegetable based diet

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It was a prospective cohort studies on diet and chronic disease in Asian women. Launched in 1996-2000, it enrolled approximately 75,000 Chinese women aged 40-70 and has tracked them for decades through follow-up surveys and health record linkage. It cites lower breast cancer risk with soy consumption and attempts to explain that Isoflavones (genistein and daidzein), which are phytoestrogens may modulate estrogen metabolism and have anti-proliferative effects on breast tissue.... but the study really demonstrates that fermented soy products (Miso, Fermented Tofu, Tempeh) not soy supplements like soy protein may be good in a traditional eastern diet Unfermented Soy (Tofu, Soy Milk, Soy Powders) are highly processed soy protein isolates or that lack the fermentation byproducts found in whole or fermented soy foods and deliver doses of isoflavones 2-3 times what you'd get from equivalent protein in tofu or tempeh

i use a glass/steel aeropress to get plastic free coffee but here is a drip machine alternative

Home | Puresteel

Drip-style coffee maker designed for wellness and longevity. Everything is stainless steel including the tank, valves, showerhead, pipe, and body.