Dan Ostermayer 's avatar
Dan Ostermayer
ostermayer@primal.net
npub1gc64...uyek
physician metabolic health maximalist πŸ“š co-sleeping https://a.co/d/0itAvPV the simple world https://a.co/d/5u4BdMU πŸ“š
Dan Ostermayer 's avatar
ostermayer 1 week ago
the best peer review is scientific experiment replication. if different groups do the same experiment over and over and get the same result there is no need for peer review. replication is the only valid peer review.
Dan Ostermayer 's avatar
ostermayer 2 weeks ago
the only thing that can be tested in a randomized double blind placebo controlled trial is a pharmaceutical intervention. everything else, even if randomized gets labeled as lesser quality evidence. (can't test organ meat ingestion and exercise this way) this is why evidence based medicine has been co-opted by drug based interventions. those molecules get the highest stamp of evidence based guidelines
Dan Ostermayer 's avatar
ostermayer 2 weeks ago
the only thing that can be tested in a randomized double placebo controlled blind trial is a pharmaceutical intervention. everything else, even if randomized gets labeled as lesser quality evidence. (can't test organ meat ingestion and exercise this way) this is why evidence based medicine has been co-opted by drug based interventions. those molecules get the highest stamp of evidence based guidelines
Dan Ostermayer 's avatar
ostermayer 2 weeks ago
file this under the obvious for must of here but a shocker for the mainstream. high saturated fat creates the cholesterol building blocks for a healthy brain "Consumption of β‰₯50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78–0.97) and VaD (HR 0.71, 95% CI 0.52–0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among APOE Ξ΅4 noncarriers (HR 0.87, 95% CI 0.76–0.99, p-interaction = 0.014). Compared with no consumption, individuals consuming β‰₯20 g/d of high-fat cream (>30% fat) had a 16% lower risk of all-cause dementia (HR 0.84, 95% CI 0.72–0.98). High-fat cream consumption was inversely associated with the risk of AD and VaD. " https://www.neurology.org/doi/10.1212/WNL.0000000000214343
Dan Ostermayer 's avatar
ostermayer 2 weeks ago
mental health flows from physical health physical health flows from mental health. "stop fixing yourself" is a great book by anthony de mello
Dan Ostermayer 's avatar
ostermayer 2 weeks ago
"This study found a significantly higher risk of influenza among the vaccinated compared to the unvaccinated state in northern Ohio during the high influenza activity period of the 2024-2025 influenza season." the vaccinated group showed a whopping 27% increased risk of contracting influenza in the months after vaccination, compared with the unvaccinated group
Dan Ostermayer 's avatar
ostermayer 3 weeks ago
the danger of proton pump inhibitors (ppi): PPI forms a covalent bond with your proton pumps and inhibit them until degenerated 72hra later. Your stomach pH goes from a highly acidic 1.5–2.0 to above 4.0 for most of the day G-cells in your stomach produce gastrin to produce more acid, but since the pumps are disabled, the stomach can’t restore normal acid levels. Stomach acid is required to cleave B12 from the proteins and with high pH the B12 won't get absorbed. Also magnesium and calcium and zinc absorption is affected. Stomach pH plays a role in converting non-heme iron (Fe3+) to the more absorbable ferrous form (Fe2+) which can't happen effectively at high pH Pepsinogen the inactive precursor to pepsin requires a low pH in order to break down protein so protein absorption is affected. Bacteria from your mouth and other areas can now colonize the upper GI tract since their growth is no longer inhibited by low pH Stomach acid inactivates C. diff spores, and PPI users have a higher risk of C. diff infection because more spores can survive to the intestines. Long-term PPI use is consistently associated with increased risk of hip and other bone fractures due to the mineral absorption issues. image
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