your stomach acid is not only an important defense against contaminants in food but also helps your intestinal biodiversity. long term antacids like proton pump inhibitors increase infectious risks and damage long term health.

The Positive Association between Proton Pump Inhibitors and Clostridium Difficile Infection - PMC

Proton pump inhibitors (PPIs) are among the most commonly used medications by patients due to its availability over the counter and frequent prescr...

https://jamanetwork.com/journals/jamapediatrics/fullarticle/2808367

goal male testosterone is 700+

spent the afternoon trying to verify the virology controls are incorrect and it does appear that universally throughout the literature cells are grown on a 10% fetal bovine serum medium, and then when it comes to the experimental phase, the medium is reduced to 2%. it seems like this justification is always for enhanced cytopathic effects to speed up experimentation. this is pretty classic in medicine where we see a protocol developed, and then it just becomes accepted in the literature that it's valid so people use it because they can publish results easily. a few really smart people know what's going on but they don't want to say anything because they need to keep collecting checks. then the medical literature becomes polluted with all the false experiments but refuting a bad idea is far harder that publishing something that supports the status quo.

Dan Ostermayer

we now have the published results from the viral control study group 

"Cell cultures were split into two distinct paths, differing only by...

a collection of historic contagion studies http://ostermayer.b-cdn.net/contagionstudies.zip

historical human to human contagion experiments https://abuiyaad.com/w/failed-contagion-experiments

people with type 2 diabetes are not just insulin resistant they are also insulin deficient. beta cells (in the pancreas) with dysfunctional mitochondria don't produce insulin in response to glucose because their mitochondria don't generate enough ATP to open the channels necessary for insulin release. their mitochondria don't work because their membranes are leaky due to PUFA (seed oil) incorporation. this causes the person's blood glucose to stays high, damaging cells. then at the skeletal muscle and liver level where the insulin is supposed to drive glucose inside, the insulin receptors are inhibited by diacylglycerol (present in all vegetable oils) which has accumulated due to mitochondrial impairment at using fatty acids. so in summary when the mitochondria are damaged the insulin isn't released as fast and then when it is released the muscle cells are inhibited from binding insulin by a pufa (diacylglycerol) that accumulates due to mitochondrial dysfunction

PubMed

Mitochondrial Dynamics and Insulin Secretion - PubMed

Mitochondria are involved in the regulation of cellular energy metabolism, calcium homeostasis, and apoptosis. For mitochondrial quality control, d...

Frontiers | Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

PubMed

Kingdom-specific lipid unsaturation calibrates sequence evolution in membrane arm subunits of eukaryotic respiratory complexes - PubMed

Sequence evolution of protein complexes (PCs) is constrained by protein-protein interactions (PPIs). PPI-interfaces are predominantly conserved and...

when you use a statin and indirectly poison your mitochondria by decreasing the available cholesterol that is used to synthesize many of the components of your electron transport chain that generates the ATP that is necessary for energy usage in your body statins inhibit the production of CoQ10 a crucial component of your mitochondria . it's been tried to mitigate the effects by supplementing with creatine and coq10 but unfortunately, with little success. then when you don't produce ATP, the cycle continues with less cholesterol utilization, which drops ATP further exacerbating the stress on your system by having less cholesterol available for use which then means less ATP available. people feel this affect with their muscle cramps went on statins because their muscles are starved of both building blocks and ATP from mitochondria poison of the statin. this is also probably the underlying mechanism for brain fog that many experience when on a statin since your brain has less ATP available.

PubMed

Creatine as a Candidate to Prevent Statin Myopathy - PubMed

Statins prevent cardiovascular diseases, yet their use is limited by the muscle disturbances they cause. Rarely, statin-induced myopathy is autoimm...

Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis - PMC

Statins are effective drugs for lowering hypercholesterolemia and preventing cardiovascular diseases. They can cause various side effects, in parti...

when you use a statin and indirectly poison your mitochondria by decreasing the available cholesterol that is used to synthesize many of the components of your electron transport chain that generates the ATP that is necessary for energy usage in your body statins inhibit the production of co-CoQ10 a crucial component of your mitochondria . it's been tried to mitigate the effects by supplementing with creatine and coq10 but unfortunately, with little success. then when you don't produce ATP, the cycle continues with less cholesterol utilization, which drops ATP further exacerbating the stress on your system by having a less cholesterol available for use which then means less a ATP available. people feel this affect with their muscle cramps went on statins because their muscles are starved of both building blocks and ATP from mitochondria poison of the statin. this is also probably the underlying mechanism for brain fog that many experience when on a statin has your brain has less ATP available.

PubMed

Creatine as a Candidate to Prevent Statin Myopathy - PubMed

Statins prevent cardiovascular diseases, yet their use is limited by the muscle disturbances they cause. Rarely, statin-induced myopathy is autoimm...

Effects of coenzyme Q10 supplementation on myopathy in statin-treated patients: a systematic review and meta-analysis - PMC

Statins are effective drugs for lowering hypercholesterolemia and preventing cardiovascular diseases. They can cause various side effects, in parti...

our teeth are constantly mineralizing and demineralizing just like our skeletal bones. they need axial loads to induce the stress that keeps them formed and strong. this comes from chewing hard things. a crucial component to that stress response is vitamin d to ensure adequate calcium uptake into the hydroxyapatite crystals – a calcium phosphate mineral that forms our teeth. Cavities are also caused by S. mutans bacterial overgrowth that is inhibited by vitamin d. modern dentistry has forgotten that chewing difficult things, keeping vitamin d high, and eating high grade mineral rich tough meats are the best cavity prevention. fluoride is not a part of our teeth's health. https://mdpi-res.com/d_attachment/nutrients/nutrients-14-04358/article_deploy/nutrients-14-04358.pdf?version=1666082161 https://journals.asm.org/doi/10.1128/aac.01675-17

The antibacterial effects of vitamin D3 against mutans streptococci: an in vitro study - PMC

This study aims to evaluate the antimicrobial effects of the cholecalciferol vitamin D3 against Streptococcus sobrinus (Strep. sobrinus) and Strept...

Secret Weapon in the Battle Against Cavities? - PMC

@Great Ghee coming in stock soon? looking to order

i think it is very possible that medicine has been fooled with the concept of contagion. it makes me uncomfortable to admit that I may have also been fooled after years in medicine as well. I have always stated my "kids got me sick" but perhaps we all spent too much time inside together or ate the same poor diets....

On the epidemiology of influenza - PMC

The epidemiology of influenza swarms with incongruities, incongruities exhaustively detailed by the late British epidemiologist, Edgar Hope-Simpson...

when are cells are sick, they release their components and we often mislabel those components as a virus that we imagine killing the cell. perhaps it is the cell death from nutritional deficiencies that creates the particles which we shed which can make people ill and turn pcr tests positive if spun at high enough cycles

Zenodo

Vero Cell Culture Image Dataset

This dataset offers a collection of light microscope and transmission electron microscope (TEM) images of Vero E6 cell cultures , primarily aimed a...

we now have the published results from the viral control study group "Cell cultures were split into two distinct paths, differing only by the concentration of fetal bovine serum (FBS) in the growth medium (Medium 1 with 10% FBS vs. Medium 2 with 2% FBS)." --> when you starve cells the nutrients they need they produce particles that look eerily similar to viruses

https://psycnet.apa.org/fulltext/2026-89350-001.pdf short form video is associated with mental health dysfunction although it is possible that people with existing mental health dysfunction like short term videos (aka tiktok and insta)

OBGYNs and primary care physicians caring for patients with PCOS (often associated with infertility) should embrace trials of ketogenesis. The benefits probably come from the elimination of garbage food and significant weight loss which helps improve the hormonal dysfunction of excess adipose (fat) tissue

this is a david's protein bar. do not eat this stuff. epg is esterified propoxylated glycerols and is a fat mimic that ruins your gut flora as it passes though undigested. natural and artificial flavors are a chemical mystery. sucralose and manitol increase hunger so you over eat also as a result of gut flora disruption.

the best detox you can do is a digital one. 1. start by spending your whole day outside hiking or biking or exploring. Keep your phone off. Doing a physical activity will make 8hrs easy. 2. Stretch your detox to two days. Over a holiday is easiest at first when "less is going on". 3. Try one week with a flip phone. Get used to printing out directions and reviving your own navigation skills. Learn to be ok not taking a picture of everything. Write down ideas until you return back home to a desktop. if you get good at this, you slowly break the habit of checking in on social media, and scrolling through news even if you have a smartphone with you. eventually, you will reactivate a brain that used to be more comfortable without disruptions than with them.

and when things are tough, "just say good" -jocko

stay hard everyone build that physical grit so you can show more emotional strength

fixed some formatting issues. metabolic health labs and ranges Core Metabolic & Glucose: 1. Fasting Insulin: < 5 µIU/mL (Optimal); Conventional "normal" often up to 25 µIU/mL. 2. Hemoglobin A1c (HbA1c): < 5.3%(Optimal); Conventional "normal" < 5.7%. 3. Fasting Glucose: 70-90 mg/dL. Lipids & Cardiovascular: 1. Triglycerides: < 80 mg/dL (Optimal); Ideally 50-70 mg/dL. 2. HDL Cholesterol: > 60 mg/dL (Men), > 70 mg/dL (Women) (Optimal). 3. LDL Cholesterol: Context-dependent(Focuses more on particle number/size if concerned, but prioritizes low Trigs/High HDL). 4. Triglyceride/HDL Ratio: < 1.0(Optimal Insulin Sensitivity Marker); < 2.0 is good. 5. Lipoprotein(a) Lp(a): < 30 mg/dL(Lower is better, strong genetic risk factor). 6. Gamma-Glutamyl Transferase (GGT): < 20 U/L (Optimal Liver/Stress Marker); Conventional normal often up to 40-60 U/L. Hormones: 1. Free T3 (Thyroid): 3.5 - 4.5 pg/mL(Upper half of range optimal for energy/metabolism). 2. Reverse T3 (rT3): < 20 ng/dL(Optimal); High levels indicate stress/conversion issues. 3. TSH: 0.5 - 2.0 µIU/mL (Optimal Function); Conventional normal often up to 4.5-5.0. 4. Total Testosterone (Men): 700 - 1100 ng/dL  5. Free Testosterone (Men): > 20 pg/mL . 6. Estradiol (Men): 20 - 30 pg/mL 7. Cortisol (AM): 12 - 18 µg/dL (Optimal morning peak). 8. DHEA-S (Men): > 350 µg/dL (Optimal for age); Women: Age-adjusted, often > 150 µg/dL. 9. Cortisol:DHEA-S Ratio: < 5x the multiplier (e.g., Cortisol 15 µg/dL / 10. DHEA-S 300 µg/dL = 0.05, which is good). Lower ratio indicates better stress resilience. Inflammation & Nutrients: 1. High-sensitivity CRP (hsCRP): < 0.5 mg/L (Optimal/Low Inflammation); < 1.0 mg/L good. 2. Homocysteine: < 8 µmol/L (Optimal); Conventional normal often up to 15 µmol/L. 3. Vitamin D (25-OH): 60 - 80 ng/mL(Optimal Immune/Function); Conventional > 30 ng/mL. 4. Magnesium (RBC): > 6.0 mg/dL(Optimal Cellular Status); Conventional serum normal often lower (1.8-2.6 mg/dL). 5. Uric Acid: < 5.5 mg/dL (Men), < 4.5 mg/dL (Women) (Lower end optimal, especially on high-purine diets). Other Key Markers: 1. Parathyroid Hormone (PTH): 15 - 30 pg/mL (Optimal, indicates good Vit D/Ca status); High levels suggest deficiency/stress. 2. IGF-1: Context-dependent (Moderate levels associated with longevity; very high may link to cancer risk). 3. ALT/AST (Liver Enzymes): < 20 U/L### Ratios Ratios: 1. Triglycerides/HDL Ratio: < 1.0 (Gold Standard for Insulin Sensitivity). 2. Cortisol/DHEA-S Ratio: Lower is better (Marker of HPA Axis Resilience).